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  7. NBI 35965 hydrochloride, Tocris Bioscience™

NBI 35965 hydrochloride, Tocris Bioscience™

Catalog Number 18075422
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Quantità:
10 mg
50 mg
Les retours ne sont pas autorisés pour ce produit. Consulta la politica di reso
603151-83-3
C21H23Cl3N4
437.793
LNYUWBPFYXPUIO-RSAXXLAASA-N
nbi 35965 hydrochloride, 7s-6-cyclopropylmethyl-2-2,4-dichlorophenyl-7-ethyl-4-methyl-7,8-dihydro-6h-1,3,6,8a-tetraazaacenaphthylene-hydrogen chloride 1/1, 7s-6-cyclopropylmethyl-2-2,4-dichlorophenyl-7-ethyl-7,8-dihydro-4-methyl-6h-1,3,6,8a-tetraazaacenaphthylene hydrochloride
71433630
CCC1CN2C3=C(C(=N2)C4=C(C=C(C=C4)Cl)Cl)N=C(C=C3N1CC5CC5)C.Cl
Les retours ne sont pas autorisés pour ce produit. Consulta la politica di reso
603151-83-3
C21H23Cl3N4
437.793
LNYUWBPFYXPUIO-RSAXXLAASA-N
nbi 35965 hydrochloride, 7s-6-cyclopropylmethyl-2-2,4-dichlorophenyl-7-ethyl-4-methyl-7,8-dihydro-6h-1,3,6,8a-tetraazaacenaphthylene-hydrogen chloride 1/1, 7s-6-cyclopropylmethyl-2-2,4-dichlorophenyl-7-ethyl-7,8-dihydro-4-methyl-6h-1,3,6,8a-tetraazaacenaphthylene hydrochloride
71433630
CCC1CN2C3=C(C(=N2)C4=C(C=C(C=C4)Cl)Cl)N=C(C=C3N1CC5CC5)C.Cl

Descrizione

Potent and selective CRF1 antagonist

Potent and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist (Ki values are 4 and > 10000 nM at CRF1 and CRF2 respectively). Inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) production in vitro (pIC50 values are 7.1 and 6.9 respectively) and attenuates CRF and ACTH production in vivo. Orally active and brain penetrant with anxiolytic activity.
Materiale o nome chimico NBI 35965 hydrochloride
Quantità 10 mg
Peso formulazione 437.79
Percent Purity >98%
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