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1,1-Dimethylbiguanide hydrochloride

Codice prodotto. 15495609
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Codice prodotto. 15495609 Fornitore Thermo Scientific Alfa Aesar N. del fornitore J63361.14
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Descrizione

An antidiabetic agent | CAS: 1115-70-4 | C4H12ClN5 | 165.63 g/mol

1,1-Dimethylbiguanide hydrochloride is used as an antidiabetic agent, used in polycystic ovary syndrome, non-alcoholic fatty liver disease and diabetes mellitus type 2. It may also reduce weight gain in people taking atypical antipsychotics, used in a study to investigate its role in enhancing the secretions of plasma active glucagon-like peptide-1 (GLP-1) levels.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• 1,1-Dimethylbiguanide consists of two guanidines with methyl substitutions at position 1

• 1,1-Dimethylbiguanide hydrochloride inhibits complex I of the mitochondrial respiratory chain, increasing AMP and activating target genes

• 1,1-Dimethylbiguanide hydrochloride enhances insulin sensitivity and fatty acid oxidation in cells

• 1,1-Dimethylbiguanide hydrochloride may also have antineoplastic action through the mammalian target of rapamycin pathway

• It is suitable for the laboratory research of diabetes, obesity, and related metabolic disorders

• It is also useful for the laboratory study of mammalian target of rapamycin (mTOR) pathways and AMPK ratios within the cell

TRUSTED_SUSTAINABILITY

Identificatori chimici

CAS 1115-70-4
Formula molecolare C4H12ClN5
Molecular Weight (g/mol) 165.63
Numero MDL MFCD00012582
InChI Key OETHQSJEHLVLGH-UHFFFAOYSA-N
Sinonimo metformin hydrochloride, 1,1-dimethylbiguanide hydrochloride, metformin hcl, glucophage, riomet, diabefagos, meguan, metformin monohydrochloride, benofomin, denkaform
PubChem CID 14219
IUPAC Name hydrogen 1-[(diaminomethylidene)amino]-N,N-dimethylmethanimidamide chloride
SMILES [H+].[Cl-].CN(C)C(=N)N=C(N)N

Specifica

Materiale o nome chimico 1,1-Dimethylbiguanide hydrochloride
Punto di fusione 218°C to 226°C
Colore White
Formula lineare NH2C(=NH)NHC(=NH)N(CH3)2·HCl
Quantità 25 g
Indice di Merck 14,5938
Informazioni di solubilità Soluble in water (50mg/ml),ethanol,and DMSO (50 mM).
Peso formulazione 165.62
Forma fisica Powder

RUO – Research Use Only

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