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4-Thiouridine, 98+%

Codice prodotto. 15463409
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15463409 100 mg 100mg
15453409 25 mg 25mg
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Codice prodotto. 15463409 Fornitore Thermo Scientific Alfa Aesar N. del fornitore J60679.MC
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Descrizione

CAS: 13957-31-8 | C9H12N2O5S | 260.26 g/mol

4-Thiouridine is a constituent of several transfer RNA's. 4-Thiouridine is a thionucleobase used as an antisense agent. Widely used for RNA analysis including RNA-RNA cross coupling and RNA labelling. 4-Thiouridine is a photoreactive (crosslinking) uridine analogue that upon phosphorylation to 4-thioUTP may be incorporated into RNA structures. 4-Thiouridine may be used to study the specificity and kinetics of uridine-cytidine kinases. 4-Thio Uridine is typically used to modify oligos slated for RNA, or RNA-protein, structural studies. A 4-thio-rU modified RNA pentamer was used to study the effect of this modification on codon-anticodon interaction when it is in the wobble position of tRNA.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
4-Thiouridine is a constituent of several transfer RNA′s. 4-Thiouridine is a thionucleobase used as an antisense agent. Widely used for RNA analysis including RNA-RNA cross coupling and RNA labelling. 4-Thiouridine is a photoreactive (crosslinking) uridine analogue that upon phosphorylation to 4-thioUTP may be incorporated into RNA structures. 4-Thiouridine may be used to study the specificity and kinetics of uridine-cytidine kinases. 4-Thio Uridine is typically used to modify oligos slated for RNA, or RNA-protein, structural studies. A 4-thio-rU modified RNA pentamer was used to study the effect of this modification on codon-anticodon interaction when it is in the wobble position of tRNA.

Solubility
Soluble in water (20 mg/ml), and methanol (10 mg/ml).

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, heat.
TRUSTED_SUSTAINABILITY

Identificatori chimici

CAS 13957-31-8
Formula molecolare C9H12N2O5S
Molecular Weight (g/mol) 260.26
Numero MDL MFCD00006538
InChI Key ZLOIGESWDJYCTF-XVFCMESISA-N
PubChem CID 3032615
ChEBI CHEBI:20480
SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(=S)NC1=O

Specifica

Materiale o nome chimico 4-Thiouridine
Colore Yellow
Quantità 100 mg
Sinonimo 4-thiouridine, thiouridine, uridine, 4-thio, 1-beta-d-ribofuranosyl-4-thiouracil, 1-2r,3r,4s,5r-3,4-dihydroxy-5-hydroxymethyl tetrahydrofuran-2-yl-4-thioxo-3,4-dihydropyrimidin-2 1h-one, 1-beta-d-ribofuranosyl-4-thioxo-3,4-dihydropyrimidin-2 1h-one, s4u, thiouridine van, uridine,4-thio, 4-thio-d-uridine
Informazioni di solubilità Soluble in water (20mg/ml),and methanol (10mg/ml).
IUPAC Name 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-sulfanylidenepyrimidin-2-one
Peso formulazione 260.27
Percent Purity ≥98%
Forma fisica Crystalline

RUO – Research Use Only

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