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  7. 6,7-Dihydroxycoumarin, 98+%

6,7-Dihydroxycoumarin, 98+%

Codice prodotto. 11488346
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Quantità:
5 g
Dimensione della confezione:
5g
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Codice prodotto. 11488346

Marca: Thermo Scientific Alfa Aesar A15393.06

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Descrizione

CAS: 305-01-1 | C9H6O4 | 178.143 g/mol

In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.

Solubility
Soluble in DMSO, DMF, diluted alkalies with blue fluorescence, and acetone. Slightly soluble in water. Insoluble in ether. Moderately soluble in Glacial acetic acid, and hot ethanol.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agents.
TRUSTED_SUSTAINABILITY

Identificatori chimici

CAS 305-01-1
Formula molecolare C9H6O4
Molecular Weight (g/mol) 178.143
Numero MDL MFCD00006874
InChI Key ILEDWLMCKZNDJK-UHFFFAOYSA-N
Sinonimo esculetin, 6,7-dihydroxycoumarin, aesculetin, cichorigenin, 6,7-dihydroxy-2h-chromen-2-one, cichoriin aglucon, esculatin, esculetol, esculin aglucon, esculin aglycon
PubChem CID 5281416
ChEBI CHEBI:490095
IUPAC Name 6,7-dihydroxychromen-2-one
SMILES C1=CC(=O)OC2=CC(=C(C=C21)O)O

Specifica

Materiale o nome chimico 6,7-Dihydroxycoumarin
Punto di fusione ∼270°C (decomposition)
Quantità 5 g
Beilstein 152788
Indice di Merck 14,3697
Informazioni di solubilità Soluble in DMSO,DMF,diluted alkalies with blue fluorescence,and acetone. Slightly soluble in water. Insoluble in ether. Moderately soluble in Glacial acetic acid,and hot ethanol.
Peso formulazione 178.15
Percent Purity ≥98%

RUO – Research Use Only

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