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AFAP1L2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marca:  Proteintech 17183-1-AP-150UL

Dettagli aggiuntivi : Peso : 0.00010kg

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Codice prodotto. 16897024

  • 349.00€ / 150µL

Spedizione stimata: 22-12-2022
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Descrizione

Descrizione

AFAP1L2, also known as XB130, is structurally similar to actin-filament-associated protein (AFAP), containing several SH2- and SH3-binding motifs, two pleckstrin homology domains, a coiled-coil region, and many potential phosphorylation sites. It interacts with and is phosphorylated by c-Src tyrosine kinase. Suppression of AFAP1L2 via siRNA reduced Src activity, IL-8 production, EGF-induced phosphorylation of Akt and GSK3beta, and altered cell cycles in human lung epithelial cells suggesting that AFAP1L2 plays a role as an adaptor in the regulation of Src signal transduction and multiple cellular functions. Recent experiments have shown that AFAP1L2 is highly expressed in thyroid and is the substrate RET/PTC kinase, a thyroid-specific kinase that plays a pathogenic role in papillary thyroid cancer. Down-regulation of AFAP1L2 in these cancer cells reduced Akt activity, inhibiting cell-cycle progression and cancer cell survival in suspension, indicating that AFAP1L2 may be a valuable target in thyroid cancer therapy. At least four isoforms of AFAP1L2 are known to exist.
Specifica

Specifica

AFAP1L2
Polyclonal
Unconjugated
AFAP1L2
AFAP1 like protein 2, AFAP1L2, KIAA1914, XB130
Rabbit
Antigen Affinity Chromatography
RUO
226250, 292130, 84632
-20°C
Liquid
Western Blot, Immunoprecipitation, Immunohistochemistry (Paraffin)
0.13 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q5DTU0, Q8N4X5
AFAP1L2
AFAP1L2 Fusion Protein Ag10966
150 μL
Primary
Rat, Mouse, Human
Antibody
IgG
Videos
SDS
Documenti

Documenti

Certificati
Offerte speciali

Offerte speciali