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AIF Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

140.00€ - 399.00€

Specifica

Antigene AIF
Concentrazione 0.39 mg/mL
Applicazioni Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classificazione Polyclonal
Coniugato Unconjugated
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Prodotti 2
Codice del prodotto Marca Quantità Prezzo Quantità e disponibilità  
Codice del prodotto Marca Quantità Prezzo Quantità e disponibilità  
16898004
Vedere i documenti Dettagli della promozione
Proteintech
17984-1-AP-20UL
20 μL
140.00€
20µL
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Spedizione stimata: 15-04-2024
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16888004
Vedere i documenti Dettagli della promozione
Proteintech
17984-1-AP-150UL
150 μL
399.00€
150µL
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Spedizione stimata: 15-04-2024
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Descrizione

Descrizione

Apoptosis Inducing Factor (AIF) causes chromatin condensation and DNA fragmentation. AIF was recently identified, and cloned. Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins. Like the critical molecules, cytochrome c and caspase-9, in apoptosis, AIF localizes in mitochondria. AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. AIF induces chromatin condensation and large scale DNA fragmentation, which are the hallmarks of apoptosis, of the isolated nucleus and the nucleus in live cells by microinjection and apoptosis stimuli. AIF is highly conserved between human and mouse and widely expressed. Mutations in the AIF gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants of AIF and a related pseudogene has been identified on chromosome 10.
Specifica

Specifica

AIF
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
Rabbit
Human, Mouse, Rat
O95831, Q9JM53, Q9Z0X1
26926, 83533, 9131
AIF Fusion Protein Ag12400
Primary
-20°C
AIFM1
0.39 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
AIF, AIFM1, PDCD8
AIFM1
IgG
Antigen Affinity Chromatography
Antibody
Videos
SDS
Documenti

Documenti

Product Certifications