missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Invitrogen™ Akirin2 Polyclonal Antibody

Descrizione
A suggested positive control is mouse brain tissue lysate. PA5-20607 can be used with blocking peptide PEP-0727.
The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappa-B-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappa-B pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-a and IL-1-b signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.
Specifica
Specifica
| Antigene | Akirin2 |
| Applicazioni | Western Blot |
| Classificazione | Polyclonal |
| Concentrazione | 1 mg/mL |
| Coniugato | Unconjugated |
| Formulazione | PBS with 0.02% sodium azide |
| Gene | AKIRIN2 |
| N. accesso geni | B1AXD8, Q53H80 |
| Alias gene | 14-3-3 beta; 2700059D21Rik; AA114675; AA522011; akirin 2; Akirin2; Akirin-2; akirin2 {ECO:0000250; AU019887; C6orf166; dJ486L4.2; EMBL:BAE81786.1}; FBI1; Fourteen-three-three beta interactant 1; fourteen-three-three beta interactant 1 {ECO:0000312; fourteen-three-three beta interacting-protein 1; RGD1307791; UniProtKB:Q53H80} |
| Simboli geni | AKIRIN2 |
| Vedi altri risultati |
Titolo del prodotto
Facendo clic su Invia, l'utente riconosce che potrebbe essere contattato da Fisher Scientific in merito al feedback fornito in questo modulo. Non condivideremo le vostre informazioni per altri scopi. Tutte le informazioni di contatto fornite saranno conservate in conformità con la nostra Politica sulla privacy. Informativa sulla privacy.
Individuate un'opportunità di miglioramento?