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Eurofins DiscoverX Akt1/PKBα (δPH, S473D) Protein, Active
Descrizione
AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. AKT activation relies on the PI3K pathway, and is recognized as a critical node in the pathway. The E17 hotspot is the most characterized of AKT1 mutations, and has been shown to result in activation of the protein. Mutations in AKT1 have also been shown to confer resistance to allosteric kinase inhibitors in vitro.
GenBank M63167. S478G with regard to this accession, reported inEMBL BE206796. S473D conflict mimics phosphorylation of S473.
Specifica
Specifica
| Formulazione | mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. |
| Peso molecolare | 45 kDa |
| Quantità | 10 μg |
| Specie | Human |
| Recombinant | Recombinant |
| Tag proteine | N-terminal 6His |
| Sistema di espressione | Recombinant enzyme expressed in Sf21 insect cells |
| Protein Form | Truncated |
| Purity or Quality Grade | ≥74% |
| Proteine | Akt1/PKBa (S473D), active |
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