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Thermo Scientific Chemicals Aldosterone, 98%

Codice prodotto. 10723411 Sfoglia Tutto Thermo Scientific Chemicals Prodotti
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Quantità:
5 mg
25 mg
100 mg
Imballaggio:
Bottiglia in vetro
Dimensione della confezione:
100mg
25mg
5mg
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Codice prodotto. Quantità Imballaggio unitSize
10723411 5 mg Bottiglia in vetro 5mg
10763724 25 mg Bottiglia in vetro 25mg
10195493 100 mg Bottiglia in vetro 100mg
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Codice prodotto. 10723411 Fornitore Thermo Scientific Chemicals N. del fornitore 215360050
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Descrizione

Aldosterone, CAS # 52-39-1, is a hormone secreted by the adrenal cortex, which regulates electrolyte and water balance by increasing the renal retention of sodium and potassium excretion.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Aldosterone is a pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland by the action of aldosterone synthase (CYP11B2)
  • It modulates electrolyte and water balance by increasing the renal retention of sodium and potassium excretion.

Applications

  • Aldosterone binds to mineralocorticoid receptors (MR; NR3C2) and MR-aldosterone complexes regulating the expression of genes involved in the retention of sodium, secretion of potassium, and water reabsorption, resulting in an increase in the blood pressure
  • In vitro, it has been involved with the pathogenesis of obesity-related glomerulopathy through activation of Wnt/β-catenin signaling in podocytes
  • Aldosterone has been used in combination with salt to induce renal injury in mice
  • It is used to stimulate primary liver sinusoidal endothelial cells
TRUSTED_SUSTAINABILITY

Identificatori chimici

CAS 52-39-1
Formula molecolare C21H28O5
Molecular Weight (g/mol) 360.45
Numero MDL MFCD00051136
InChI Key PQSUYGKTWSAVDQ-ZVIOFETBSA-N
Sinonimo aldosterone, electrocortin, aldocortin, aldocorten, aldocortene, +-aldosterone, elektrocortin, d-aldosterone, reichstein x, 18-oxocorticosterone
PubChem CID 5839
ChEBI CHEBI:27584
IUPAC Name (8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde
SMILES CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C=O)O

Specifica

Materiale o nome chimico Aldosterone
Nota nome 98%
CAS min. % 97.5
CAS max % 100.0
Colore White
Perdita all'essiccatura 6.0% max. (105°C, 3 hrs)
Spettro a infrarossi Authentic
Intervallo percentuale saggio 98%
Imballaggio Bottiglia in vetro
Quantità 5 mg
Beilstein 08, IV, 3491
Indice di Merck 15, 218
Rotazione specifica +150° to +162° (20°C, 589nm) (c=0.1, CHCl3)
Peso formulazione 360.45
Percent Purity ≥97.5% (HPLC)
Forma fisica Crystalline Powder
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RUO – Research Use Only

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