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  6. CD11b Rat anti-Mouse, PerCP-Cy5.5, Clone: M1/70, BD

CD11b Rat anti-Mouse, PerCP-Cy5.5, Clone: M1/70, BD

Codice prodotto. 15810789
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Quantità:
0.1 mg
25 μg
Dimensione della confezione:
Pezzo
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Codice prodotto. Quantità unitSize
15810789 25 μg Pezzo
15846468 0.1 mg Pezzo
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Codice prodotto. 15810789 Fornitore BD Biosciences N. del fornitore 561114

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Descrizione

Rat Monoclonal Antibody

The M1/70 monoclonal antibody specifically binds to CD11b, also known as Integrin alpha M (Itgam or α;M) . CD11b is a 170-kDa type 1 transmembrane glycoprotein and belongs to the Integrin alpha chain family. CD11b serves as the alpha chain of the heterodimeric Mac-1 integrin (CD11b/CD18, α;Mβ;2), also known as complement receptor 3 (CR3) . Mac-1 mediates adhesion to ICAM-1 (CD54), ICAM-2 (CD102), fibrinogen and binding to C3bi. Mac-1 is expressed at varying levels on granulocytes, macrophages, myeloid-derived dendritic cells, natural killer cells, microglia, and B-1 B lymphocytes. Mac-1 expression is rapidly up-regulated on neutrophils after activation, in the same time period that CD62L (L-selectin) is shed from the cell surface. The M1/70 antibody reportedly blocks cell adherence and C3bi binding but does not block cell-mediated lysis. Cross-reaction of the M1/70 antibody with CD11b expressed on human monocytes, polymorphonuclear leukocytes, and NK cells has been reported.
TRUSTED_SUSTAINABILITY

Specifica

Antigene CD11b
Applicazioni Flow Cytometry
Classificazione Monoclonal
Clone M1/70
Concentrazione 0.2mg/mL
Coniugato PerCP-Cyanine5.5
Descrizione Itgam; Integrin alpha-M; Ly-40; Mac-1a; Mac-1 alpha; CR3A; CR-3 alpha chain
Formulazione Aqueous buffered solution containing ≤0.09% sodium azide.
Specie ospite Rat
Immunogeno Mouse Splenic Cells
Metodo di purificazione Affinity Purified
Quantità 25 μg
Status giuridico RUO
Primario o secondario Primary
Target Species Human, Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2b κ
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For Research Use Only.

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