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Invitrogen™ APS Polyclonal Antibody
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Codice prodotto. 11582500
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Quantità:
100 μL
Dimensione della confezione:
100µL
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Codice prodotto. Quantità unitSize
11582500 100 μL 100µL
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Codice prodotto. 11582500 Fornitore Invitrogen™ N. del fornitore PA517608

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Descrizione

Rabbit Polyclonal Antibody

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with other adaptor/docking proteins.

APS (adapter protein with Pleckstrin homology and Src homology 2 domains) a member of the Lnk family, is an adaptor protein that is involved in B-cell signaling, insulin signaling, cytoskeletal reorganization. It is tyrosine phosphorylated by JAK2, KIT and other kinases during B-cell receptor stimulation of many different cytokines, chemokines and leukokines. APS has been shown to inhibit the JAK-STAT pathway in collaboration with c-Cbl. It is located in the cytoplasm in pre-PDGF (platelet derived growth factor) stimulated cells and localizes to the plasma membrane and peripheral regions upon PDGF stimulation. This protein is expressed in B-cells and mast cells when detected in haematopoietic cell lines yet is also expressed in many different tissues including spleen, prostrate, testis, uterus, small intestine and skeletal muscle.
TRUSTED_SUSTAINABILITY

Specifica

Antigene APS
Applicazioni Immunohistochemistry (Paraffin), Western Blot
Classificazione Polyclonal
Concentrazione 78 μg/mL
Coniugato Unconjugated
Formulazione 0.01M HEPES with 100 μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
Gene SH2B2
N. accesso geni O14492, Q9JID9
Alias gene adapter protein with pleckstrin homology and Src homology 2 domains; adaptor protein with pleckstrin homology and src homology 2 domains; Alpha-1-antitrypsin; Aps; SH2 and PH domain-containing adapter protein APS; SH2B adapter protein 2; SH2B adaptor protein 2; Sh2b2
Simboli geni SH2B2
Specie ospite Rabbit
Immunogeno Synthetic peptide corresponding to residues near the amino-terminus of human APS.
Metodo di purificazione Antigen affinity chromatography
Quantità 100 μL
Status giuridico RUO
Primario o secondario Primary
ID gene (immissione) 10603, 23921
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Forma Liquid
Isotype IgG
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