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beta-Estradiol, 99% (dry wt.), ca 3% water
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Description
β-Estradiol is the major estrogen secreted by the premenopausal ovary. It acts as an estrogenic hormone receptor (ER) agonist and activator of PI 3-kinase. Further, it is used in the treatment of infertility in women, prostate cancer and breast cancer. It is also employed as an agent of stimulating female puberty induction, as in the treatment of delayed puberty caused by hypogonadism or Turner's syndrome. In addition to this, it is used as part of the hormone replacement therapy for transgender women.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
β-Estradiol is the major estrogen secreted by the premenopausal ovary. It acts as an estrogenic hormone receptor (ER) agonist and activator of PI 3-kinase. Further, it is used in the treatment of infertility in women, prostate cancer and breast cancer. It is also employed as an agent of stimulating female puberty induction, as in the treatment of delayed puberty caused by hypogonadism or Turner′s syndrome. In addition to this, it is used as part of the hormone replacement therapy for transgender women.
Solubility
Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils.
Notes
Incompatible with strong oxidizing agents.
Specifications
Specifications
| Materiale o nome chimico | beta-Estradiol |
| Punto di fusione | 175°C to 178°C |
| Note percentuale saggio | (dry wt.), ≈3% water |
| Quantità | 1 g |
| Beilstein | 1914275 |
| Indice di Merck | 14,3703 |
| Informazioni di solubilità | Soluble in dimethyl sulfoxide,ethanol ,water,phosphate buffer saline,dimethyl formamide,acetone,dioxane and alkali hydroxides. Slightly soluble in vegetable oils. |
| Optical Rotation | +79° (c=1 in Dioxane) |
| Peso formulazione | 272.39 |
| Percent Purity | 99% |
Safety and Handling
- beta-Estradiol
- Pericolo
- cancerogenicità Categoria 1A
- Tossicità per la riproduzione sull'allattamento o attraverso l'allattamento
- Tossicità per la riproduzione Categoria 2
- Tossicità specifica per organi bersaglio (esposizione ripetuta) Categoria 2
- H350-Può provocare il cancro.
- H361fd-Sospettato di nuocere alla fertilità Sospettato di nuocere al feto.
- H362-Può essere nocivo per i lattanti allattati al seno.
- H373-Può provocare danni agli organi.
- P201-Procurarsi istruzioni specifiche prima dell'uso.
- P202-Non manipolare prima di avere letto e compreso tutte le avvertenze.
- P260-Non respirare la polvere/i fumi/i gas/la nebbia/i vapori/gli aerosol.
- P263-Evitare il contatto durante la gravidanza/l'allattamento.
- P280-Indossare guanti/indumenti protettivi/Proteggere gli occhi/il viso.
- P308+P313-IN CASO di esposizione o di possibile esposizione, consultare un medico.
- MIXTURE LIST-Contain: Estradiol-17b
RUO – Research Use Only
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