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DiscoverX cAMP Hunter™ CHO-K1 CXCR4 Gi Cell Line

Codice prodotto. 17354539
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Quantità:
2 Vials
Dimensione della confezione:
2 fiale
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Codice prodotto. Quantità unitSize
17354539 2 Vials 2 fiale
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Codice prodotto. 17354539 Fornitore DiscoverX N. del fornitore 950081C2

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Les retours ne sont pas autorisés pour ce produit. Consulta la politica di reso

Descrizione

The cAMP Hunter™ CHO-K1 CXCR4 Gi Cell Line measures CXCR4 (GPCR) activity via decreased levels of intracellular cAMP. This cell line ships as two vials of cryopreserved cells.

The cAMP Hunter CXCR4 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CXCL12/SDF-1α) based activation of CXCR4 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wildtype CXCR4 , a naturally Gi/Go coupled GPCR. Upon activation of CXCR4 , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifica

Assay Entry Intracellular cAMP level
Linea cellulare CHO-K1
Da utilizzare con (applicazione) Cell Lines
Primary Agonist Recombinant Human SDF-1α (CXCL12)
Quantità 2 Vials
Target Entry CXCR4
Numero di accesso AY242129
Titolo del prodotto
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