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Invitrogen™ Caspase 3 (Cleaved Asp175) Polyclonal Antibody

Codice prodotto. 17227453 Sfoglia Tutto Thermo Scientific Prodotti
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Quantità:
100 μL
Dimensione della confezione:
100µL
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Codice prodotto. Quantità Dimensione della confezione
17227453 100 μL 100µL
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Product Code. 17227453 Supplier Invitrogen™ Supplier No. PA5114687
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of fragment of activated Caspase 3 resulting from cleavage adjacent to Asp175.

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigene Caspase 3 (Cleaved Asp175)
Applicazioni Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classificazione Polyclonal
Concentrazione 1 mg/mL
Coniugato Unconjugated
Formulazione PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene CASP3
N. accesso geni P42574, P55213, P70677
Alias gene A830040C14Rik; AC-3; Apopain; Casp3; CASP-3; caspase 3; Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis related cysteine protease; Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; Caspase-3; Caspase-3 subunit p12; Caspase-3 subunit p17; CC3; Cpp32; CPP-32; CPP32B; CPP32beta; cysteine protease CPP32; IRP; Lice; mldy; PARP cleavage protease; procaspase3; protein Yama; SCA-1; SREBP cleavage activity 1; Yama; yama protein
Simboli geni CASP3
Specie ospite Rabbit
Immunogeno A synthesized peptide derived from human CASP3(Accession P42574), corresponding to amino acid residues C163-M182.
Metodo di purificazione Affinity chromatography
Quantità 100 μL
Status giuridico RUO
Primario o secondario Primary
ID gene (immissione) 12367, 25402, 836
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Forma Liquid
Isotype IgG
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