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DiscoverX ChemiBrite™ EP3 Prostanoid Receptor Stable Cell Line

Codice prodotto. 17345169
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Quantità:
2 Vials
Dimensione della confezione:
2 fiale
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Codice prodotto. Quantità unitSize
17345169 2 Vials 2 fiale
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Codice prodotto. 17345169 Fornitore DiscoverX N. del fornitore HTS092L

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Les retours ne sont pas autorisés pour ce produit. Consulta la politica di reso

Descrizione

The ChemiBrite™ EP3 Prostanoid Receptor Stable Cell Line measures PTGER3 (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.

The ChemiBrite EP3 Prostanoid Receptor cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin E2) based activation of PTGER3 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PTGER3 alongside exogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of PTGER3 , the resulting calcium activity can be assayed in either detection mode. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifica

Assay Entry Calcium Flux
Linea cellulare 293H
Da utilizzare con (applicazione) Cell Lines
Primary Agonist Prostaglandin E2
Quantità 2 Vials
Target Entry PTGER3
Numero di accesso NM_198716
Titolo del prodotto
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