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DiscoverX ChemiScreen™ CCR7 Chemokine Receptor Stable Cell Line

Codice prodotto. 17384969
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Quantità:
2 Vials
Dimensione della confezione:
2 fiale
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Codice prodotto. Quantità unitSize
17384969 2 Vials 2 fiale
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Codice prodotto. 17384969 Fornitore DiscoverX N. del fornitore HTS012C

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Les retours ne sont pas autorisés pour ce produit. Consulta la politica di reso

Descrizione

The ChemiScreen™ CCR7 Chemokine Receptor Stable Cell Line measures CCR7 (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.

The ChemiScreen™ CCR7 Chemokine Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CCL19) based activation of CCR7 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CCR7 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CCR7 , the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifica

Assay Entry Calcium Flux
Linea cellulare Chem-1
Da utilizzare con (applicazione) Cell Lines
Primary Agonist Recombinant Human MIP-3β (CCL19)
Quantità 2 Vials
Target Entry CCR7
Numero di accesso AY587876
Titolo del prodotto
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