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Description
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- Cycloheximide is a semisynthetic compound showing an antifungal antibiotic activity.
- It is produced by the bacterium Streptomyces griseus
- Cycloheximide can inhibit protein synthesis in eukaryotic cells but not in prokaryotes by interacting directly with the translocase enzyme and interfering with the translocation step. Furthermore, this compound also blocks the A site of ribosomes
Application
- Cycloheximide shows a neuroprotective, fungicide, and anticoronaviral activities
- In biomedical research, it can induce glycogenolysis, gluconeogenesis, and ureagenesis
- Due to significant toxic side effects such as teratogenesis, DNA damage, birth defects, and toxicity to sperm, this chemical compound is only used in in vitro research applications
- This compound also shows inhibitory activity against ferroptosis
- It is also used in laboratory media as a selective agent to permit the isolation of pathogenic and non-pathogenic fungi from other types of specimens
- In laboratory research related to plant biology, it can induce ethylene production to promote the plant growth
- In laboratory research, this compound can be applied to determine the half-life of protein in any cellular system. The treatment of in vitro cells with cycloheximide in a time-course experiment followed by western blotting using this cell lysate can show differences in protein half-life.
Spécification
Spécification
| Materiale o nome chimico | Cycloheximide |
| Punto di fusione | 107.0°C to 114.0°C |
| Colore | White |
| Spettro a infrarossi | Authentic |
| Intervallo percentuale saggio | 94% min. (HPLC) |
| Imballaggio | Bottiglia in vetro |
| Quantità | 5 g |
| Indice di Merck | 15,2721 |
| Condizione di rotazione specifica | − 28.50 (20.00°C c=1,CHCl3) |
| Rotazione specifica | − 28.50 |
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Sécurité et traitement
- Cycloheximide
- Pericolo
- Tossicità acuta Categoria 2
- PERICOLO A LUNGO TERMINE PER L'AMBIENTE ACQUATICO Cronico 2
- Mutagenicità di cellule germinali Categoria 2
- Tossicità per la riproduzione Categoria 1B
- H360D-Può nuocere al feto.
- H341-Sospettato di provocare alterazioni genetiche.
- H411-Tossico per gli organismi acquatici con effetti di lunga durata.
- H300-Letale se ingerito.
- P201-Procurarsi istruzioni specifiche prima dell'uso.
- P273-Non disperdere nell'ambiente.
- P280-Indossare guanti/indumenti protettivi/Proteggere gli occhi/il viso.
- P301+P310-IN CASO DI INGESTIONE: contattare immediatamente un CENTRO ANTIVELENI/un medico
- P308+P313-IN CASO di esposizione o di possibile esposizione, consultare un medico.
RUO – Research Use Only
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