Thermo Scientific Chemicals Cycloheximide, 95%

General Description

• Cycloheximide is a semisynthetic compound showing an antifungal antibiotic activity.
• It is produced by the bacterium Streptomyces griseus
• Cycloheximide can inhibit protein synthesis in eukaryotic cells but not in prokaryotes by interacting directly with the translocase enzyme and interfering with the translocation step. Furthermore, this compound also blocks the A site of ribosomes

Application

• Cycloheximide shows a neuroprotective, fungicide, and anticoronaviral activities
• In biomedical research, it can induce glycogenolysis, gluconeogenesis, and ureagenesis
• Due to significant toxic side effects such as teratogenesis, DNA damage, birth defects, and toxicity to sperm, this chemical compound is only used in in vitro research applications
• This compound also shows inhibitory activity against ferroptosis
• It is also used in laboratory media as a selective agent to permit the isolation of pathogenic and non-pathogenic fungi from other types of specimens
• In laboratory research related to plant biology, it can induce ethylene production to promote the plant growth
• In laboratory research, this compound can be applied to determine the half-life of protein in any cellular system. The treatment of in vitro cells with cycloheximide in a time-course experiment followed by western blotting using this cell lysate can show differences in protein half-life.