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Thermo Scientific Chemicals Cycloheximide, 95%

Product Code. 10286291 Shop All Thermo Scientific Chemicals Products
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Description

Cycloheximide, CAS # 66-81-9, is a compound produced by the bacterium Streptomyces griseus that shows an antifungal antibiotic activity with the ability to inhibit protein synthesis only in eukaryotic cells.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Cycloheximide is a semisynthetic compound showing an antifungal antibiotic activity.
  • It is produced by the bacterium Streptomyces griseus
  • Cycloheximide can inhibit protein synthesis in eukaryotic cells but not in prokaryotes by interacting directly with the translocase enzyme and interfering with the translocation step. Furthermore, this compound also blocks the A site of ribosomes

Application

  • Cycloheximide shows a neuroprotective, fungicide, and anticoronaviral activities
  • In biomedical research, it can induce glycogenolysis, gluconeogenesis, and ureagenesis
  • Due to significant toxic side effects such as teratogenesis, DNA damage, birth defects, and toxicity to sperm, this chemical compound is only used in in vitro research applications
  • This compound also shows inhibitory activity against ferroptosis
  • It is also used in laboratory media as a selective agent to permit the isolation of pathogenic and non-pathogenic fungi from other types of specimens
  • In laboratory research related to plant biology, it can induce ethylene production to promote the plant growth
  • In laboratory research, this compound can be applied to determine the half-life of protein in any cellular system. The treatment of in vitro cells with cycloheximide in a time-course experiment followed by western blotting using this cell lysate can show differences in protein half-life.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 66-81-9
Formula molecolare C15H23NO4
Molecular Weight (g/mol) 281.35
Numero MDL MFCD00082346
InChI Key YPHMISFOHDHNIV-QTEFRXOUNA-N
Sinonimo cycloheximide, actidione, cycloheximide, naramycin a, kaken, actidion, actidone, hizarocin, naramycin, neocycloheximide
PubChem CID 6197
ChEBI CHEBI:27641
IUPAC Name 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione
SMILES [H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC1CC(=O)NC(=O)C1

Specifications

Materiale o nome chimico Cycloheximide
Punto di fusione 107.0°C to 114.0°C
Colore White
Spettro a infrarossi Authentic
Intervallo percentuale saggio 94% min. (HPLC)
Imballaggio Bottiglia in vetro
Quantità 1 g
Indice di Merck 15,2721
Condizione di rotazione specifica − 28.50 (20.00°C c=1,CHCl3)
Rotazione specifica − 28.50
Informazioni di solubilità Solubility in water: 2.1 g/100mL (2 c). Other solubilities: soluble in chloroform, ether, acetone, methanol, and ethanol
Peso formulazione 281.35
Percent Purity 95%
Forma fisica Glassy Irregular Shaped Granules
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Safety and Handling

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Product Identifier
  • Cycloheximide
 Signal Word
  • Pericolo
 Hazard Category
  • Tossicità acuta Categoria 2
  • PERICOLO A LUNGO TERMINE PER L'AMBIENTE ACQUATICO Cronico 2
  • Mutagenicità di cellule germinali Categoria 2
  • Tossicità per la riproduzione Categoria 1B
 Hazard Statement
  • H360D-Può nuocere al feto.
  • H341-Sospettato di provocare alterazioni genetiche.
  • H411-Tossico per gli organismi acquatici con effetti di lunga durata.
  • H300-Letale se ingerito.
 Precautionary Statement
  • P201-Procurarsi istruzioni specifiche prima dell'uso.
  • P273-Non disperdere nell'ambiente.
  • P280-Indossare guanti/indumenti protettivi/Proteggere gli occhi/il viso.
  • P301+P310-IN CASO DI INGESTIONE: contattare immediatamente un CENTRO ANTIVELENI/un medico
  • P308+P313-IN CASO di esposizione o di possibile esposizione, consultare un medico.
SDS

RUO – Research Use Only

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