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ACROBiosystems Cynomolgus TREM2 Protein, His Tag
457.25€ - 3357.52€
Specifica
Numero di accesso | XP_015304910.1 |
---|---|
Peso molecolare | 19.3 kDa |
Sorgente | Cynomolgus TREM2, His Tag (TR2-C52H3) is expressed from human 293 cells (HEK293). It contains AA His 19 - Ser 174 (Accession # A0A2K5UY39-1). |
Immunogeno | His 19 - Ser 174 |
Requisiti di stoccaggio | -20°C |
Codice del prodotto | Marca | Quantità | Prezzo | Quantità e disponibilità | |||||
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Codice del prodotto | Marca | Quantità | Prezzo | Quantità e disponibilità | |||||
17236590
|
ACROBiosystems
TR2-C52H3-100UG |
100 μg |
457.25€
100µg |
Spedizione stimata: 02-05-2024 Eseguire il login per visualizzare lo stock disponibile |
Effettua il login per acquistare questo articolo Hai bisogno di un conto web ? Registrati oggi stesso! | ||||
17246590
|
ACROBiosystems
TR2-C52H3-1MG |
1 mg |
3357.52€
1mg |
Spedizione stimata: 02-05-2024 Eseguire il login per visualizzare lo stock disponibile |
Effettua il login per acquistare questo articolo Hai bisogno di un conto web ? Registrati oggi stesso! | ||||
Descrizione
Triggering receptor expressed on myeloid cells 2 (TREM2) is a cell surface receptor of the immunoglobulin superfamily. The TREM2 is found in various tissue macrophages, such as CNS microglia, bone osteoclasts, alveolar, peritoneal and intestinal macrophages. TREM2 is also present on cultured bone marrow-derived macrophages and monocyte-derived dendritic cells. Some research have identified a rare variant of TREM2 that is a risk factor for Alzheimer disease (AD), which is the most common form of late-onset dementia.The extracellular region of TREM2 contains a single immunoglobulin superfamily domain and binds polyanionic ligands, such as bacterial lipopolysaccharide (LPS) and phospholipids8. Upon ligand binding, TREM2 transmits intracellular signals through an adaptor, DAP12 (also known as TYRO protein tyrosine kinase-binding protein (TYROBP)), which is associated with the transmembrane region of TREM2 and which recruits the protein tyrosine kinase SYK through its cytosolic immunoreceptor tyrosine-based activation motifs (ITAMs). TREM2 is a pro-tumorigenic marker of tumor-infiltrating macrophages in mouse models and human tumors that can be targeted to curb tumor growth and improve the efficacy of checkpoint blockade therapy while remodeling the landscape of tumor-infiltrating macrophages.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 19.3 kDa. The protein migrates as 30-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Specifica
XP_015304910.1 | |
Cynomolgus TREM2, His Tag (TR2-C52H3) is expressed from human 293 cells (HEK293). It contains AA His 19 - Ser 174 (Accession # A0A2K5UY39-1). | |
-20°C | |
TREM2 | |
Cynomolgus Monkey | |
PBS, pH7.4 | |
HEK293 | |
Immune Checkpoint Proteins |
19.3 kDa | |
His 19 - Ser 174 | |
Triggering receptor expressed on myeloid cells 2/TREM2/TREM-2 | |
Unconjugated | |
His Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>90% as determined by SDS-PAGE. |