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  7. Thermo Scientific Chemicals D-Cycloserine, 98%

Thermo Scientific Chemicals D-Cycloserine, 98%

Codice prodotto. 10683062 Sfoglia Tutto Thermo Scientific Chemicals Prodotti
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25 g
Imballaggio:
Bottiglia in vetro
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1g
25g
5g
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10683062 1 g Bottiglia in vetro 1g
10450501 5 g Bottiglia in vetro 5g
10646734 25 g Bottiglia in vetro 25g
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Codice prodotto. 10683062 Fornitore Thermo Scientific Chemicals N. del fornitore 228480010
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Beskrivning

D-Cycloserine, CAS # 68-41-7, is a cyclic amino acid analog of D-alanine, originally isolated from Streptomyces species. It is synthetically formulated and exhibits antibiotic properties through its inhibition of bacterial cell wall synthesis.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

  • D-Cycloserine was originally isolated from Streptomyces orchidaceus and is currently formulated as an oral antibiotic
  • It is incompatible with strong oxidizing agents but stable under basic conditions, with the greatest stability at pH = 11.5
  • D-Cycloserine inhibits L-alanine racemase and D-alanine:D-alanine ligase, 2 enzymes responsible for bacterial cell wall synthesis
  • When ingested, D-Cycloserine traverses the blood-brain barrier, potentially causing neurological side effects such as, dizziness, nausea, depression, tremors, etc.

Applications

  • D-Cycloserine is a broad-spectrum antibiotic used as a second line agent for treatment of drug-resistant tuberculosis, always in combination with other antituberculosis agents
  • It is an excitatory amino acid and partial agonist of the NMDA receptor in the central nervous system (CNS), thus playing a potential role in the amelioration of neuropathic pain
  • D-Cycloserine has also been shown to play a role in neural connectivity, and is therefore used to study treatment applications in anxiety disorders and schizophrenia
TRUSTED_SUSTAINABILITY

Kemiska identifierare

CAS 68-41-7
Formula molecolare C3H6N2O2
Molecular Weight (g/mol) 102.09
Numero MDL MFCD00005353
InChI Key DYDCUQKUCUHJBH-UWTATZPHSA-N
Sinonimo d-cycloserine, cycloserine, seromycin, orientomycin, oxamycin, cyclorin, cyclo-d-serine, cicloserina, farmiserina, miroseryn
PubChem CID 6234
ChEBI CHEBI:40009
IUPAC Name (4R)-4-amino-1,2-oxazolidin-3-one
SMILES C1C(C(=O)NO1)N

Specifikationer

Materiale o nome chimico D-Cycloserine
Nota nome 98+%
Absorbance Condensation products 0.8 max. (c=0.04, 0.1N NaOH) at 285nm
Punto di fusione 147.0°C
Colore White to Yellow
pH 5.5 to 6.5 (10% soln.)
Residuo della combustione 0.5% max. ()
Perdita all'essiccatura 1% max. (60°C, 3 hrs) (vacuum)
Spettro a infrarossi Authentic
Intervallo percentuale saggio 98%
Imballaggio Bottiglia in vetro
Quantità 1 g
Indice di Merck 15,2749
Rotazione specifica + 111.00
Informazioni di solubilità Solubility in water: soluble. Other solubilities: slightly soluble in methanol and propylene glycol
Peso formulazione 102.09
Percent Purity 98%
Forma fisica Crystalline Powder or Crystals
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RUO – Research Use Only

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