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DELE Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Marca:  Thermo Scientific PA557712

Dettagli aggiuntivi : Peso : 0.02000kg

Codice prodotto. 15785601

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Descrizione

Descrizione

Immunogen sequence: PLDRFFSSPL WHPCSSLRQH ILPSPDGPAP RHTGLREPRL GQEEASAQPR NFSHNSLRGA RPQDPSEEGP GDFGFLHASS SIESEAKPAQ P Highest antigen sequence identity to the following orthologs: Mouse - 55%, Rat - 59%.

DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-Alpha and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-Alpha, anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.
Specifica

Specifica

DELE
Polyclonal
Unconjugated
KIAA0141
DELE, Death ligand signal enhancer, KIAA0141
Rabbit
Antigen affinity chromatography
RUO
9812
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry
0.3 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Q14154
KIAA0141
Recombit protein corresponding to Human DELE
100 μL
Primary
Human
Antibody
IgG
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