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Thermo Scientific Chemicals DL-1,4-Dithiothreitol, 99%, for biochemistry

Codice prodotto. 10448730 Sfoglia Tutto Thermo Scientific Chemicals Prodotti
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Codice prodotto. 10448730

Marca: Thermo Scientific Chemicals 165680010

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Description

1,4-Dithiothreitol, CAS # 3483-12-3, is a reducing agent commonly used to reduce disulphide bonds in protein studies, such as western blot SDS-page electrophoresis. | CAS: 3483-12-03 | C4H10O2S2 | 154.25 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

  • 1,4-Dithiothreitol (DTT or Cleland's reagent) reduces disulfide bonds in proteins, leading to loss of native conformation
  • DTT is not stable in solution and should be prepared in small aliquots prior to use; the use of EDTA in the solution can increase the half-life of DTT
  • Typically used at a final concentration of 0.1M for protein stabilization; recommended to create a 1M stock

Applications

  • Protects thiol groups from oxidation and acts as a chemical chelator in solution; maintains proteins in the denatured state
  • Common applications include SDS-page electrophoresis and protein isolation
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 3483-12-03
Numero MDL MFCD00004877
InChI Key VHJLVAABSRFDPM-IMJSIDKUSA-N
Sinonimo dithiothreitol, dl-1,4-dithiothreitol, dl-dithiothreitol, 1,4-dithio-dl-threitol, d-1,4-dithiothreitol, d-dtt, 2s,3s-1,4-dimercaptobutane-2,3-diol, threo-1,4-dimercapto-2,3-butanediol, 1,4-dithiothreitol, dtt
PubChem CID 446094
ChEBI CHEBI:42170
IUPAC Name (2S,3S)-1,4-bis(sulfanyl)butane-2,3-diol
SMILES C(C(C(CS)O)O)S

Specifications

Materiale o nome chimico DL-1, 4-Dithiothreitol
Absorbance (1 M soln. in water), (1 M soln. in water) at 0nm, 0.035 max. at 500nm
Punto di fusione 39°C to 44°C
Colore White
Spettro a infrarossi Authentic
Intervallo percentuale saggio 0.99
Formula molecolare C4H10O2S2
Formula lineare HSCH2CH(OH)CH(OH)CH2SH
Quantità 1 g
Beilstein 01, III, 2360
Indice di Merck 15, 3419
Trasmittanza 99% min. (c=5, 660nm, water) 1cm cell
Molecular Weight (g/mol) 154.24
Peso formulazione 154.24
Percent Purity ≥98.5%
Grado Biochemical
Forma fisica Powder
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Safety and Handling

compliance-icons
Product Identifier
  • DL-1,4-Dithiothreitol
 Signal Word
  • Attenzione
 Hazard Category
  • Tossicità acuta Categoria 4
  • Lesione oculare grave/irritazione oculare Categoria 2
  • Corrosione/irritazione della pelle Categoria 2
  • Tossicità specifica per organi bersaglio (esposizione singola) Categoria 3
 Hazard Statement
  • H315-Provoca irritazione cutanea.
  • H319-Provoca grave irritazione oculare.
  • H335-Può irritare le vie respiratorie.
  • H302-Nocivo se ingerito.
 Precautionary Statement
  • P261-Evitare di respirare la polvere/i fumi/i gas/la nebbia/i vapori/gli aerosol.
  • P280-Indossare guanti/indumenti protettivi/Proteggere gli occhi/il viso.
  • P301+P312-IN CASO DI INGESTIONE accompagnata da malessere: contattare un CENTRO ANTIVELENI/medico/
  • P302+P352-IN CASO DI CONTATTO CON LA PELLE: lavare abbondantemente con acqua/.
  • P305+P351+P338-IN CASO DI CONTATTO CON GLI OCCHI: sciacquare accuratamente per parecchi minuti. Togliere le eventuali lenti a contatto se è agevole farlo. Continuare a sciacquare.
  • P332+P313-In caso di irritazione della pelle: consultare un medico.
  • P337+P313-Se l'irritazione degli occhi persiste, consultare un medico.
SDS

RUO – Research Use Only

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