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  7. DL-Thioctic acid, 98%

DL-Thioctic acid, 98%

Codice prodotto. 11321687
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Codice prodotto. 11321687 Fornitore Thermo Scientific Alfa Aesar N. del fornitore L04711.06
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Description

DL-Thioctic acid, CAS # 1077-28-7, is an antioxidant and coenzyme important for the activity of enzymes. | CAS: 1077-28-7 | C8H14O2S2 | 206.32 g/mol

DL-Thioctic acid plays an essential role in aerobic metabolism. Further, it acts as a free radical scavenger.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• DL-Thioctic acid derives from octanoic acid, and it has been described as an antioxidant coenzyme important for the activity of enzyme complexes including pyruvate dehydrogenase and glycine decarboxylase

Application

• DL-Thioctic acid has been used in studies to increase insulin sensitivity and stimulate glucose uptake into adipose and muscle cells in vitro

• DL-Thioctic acid has an essential role in aerobic metabolism

• It has been used as free radical scavenger compound

• It can also assist in repairing oxidative damage via the increase of endogenous antioxidants, including vitamins C, vitamin E, and glutathione

• It can induce apoptosis through caspase-independent and caspase-dependent pathways, a process mediated by intracellular Ca2+

• DL-Thioctic acid has the ability to impact various cellular biological pathways since it can increase glutathione synthesis and modulate transcription factor activity, mainly nuclear factor kappa B (NF-κB)

• It can decrease the phagocytosis of myelin by macrophages

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 1077-28-7
Formula molecolare C8H14O2S2
Molecular Weight (g/mol) 206.32
Numero MDL MFCD00005474
InChI Key AGBQKNBQESQNJD-UHFFFAOYNA-N
Sinonimo dl-thioctic acid, thioctic acid, alpha-lipoic acid, 5-1,2-dithiolan-3-yl pentanoic acid, dl-alpha-lipoic acid, 1,2-dithiolane-3-pentanoic acid, 6,8-thioctic acid, thioctacid, 6-thioctic acid, alpha lipoic acid
PubChem CID 864
ChEBI CHEBI:16494
IUPAC Name 5-(1,2-dithiolan-3-yl)pentanoic acid
SMILES OC(=O)CCCCC1CCSS1

Specifications

Materiale o nome chimico DL-Thioctic acid
Punto di fusione 59°C to 63°C
Punti di ebollizione 160°C to 165°C
Quantità 5 g
Beilstein 81853
Indice di Merck 14,9326
Informazioni di solubilità Soluble in methanol,ethanol,diethyl ether and chloroform. Insoluble in water.
Peso formulazione 206.33
Percent Purity 98%

Safety and Handling

compliance-icons
Product Identifier
  • DL-Thioctic acid
 Signal Word
  • Attenzione
 Hazard Category
  • Tossicità acuta Categoria 4
  • Lesione oculare grave/irritazione oculare Categoria 2
  • Corrosione/irritazione della pelle Categoria 2
  • Tossicità specifica per organi bersaglio (esposizione singola) Categoria 3
 Hazard Statement
  • H302-Nocivo se ingerito.
  • H315-Provoca irritazione cutanea.
  • H319-Provoca grave irritazione oculare.
  • H335-Può irritare le vie respiratorie.
 Precautionary Statement
  • P280-Indossare guanti/indumenti protettivi/Proteggere gli occhi/il viso.
  • P301+P330+P331-IN CASO DI INGESTIONE: sciacquare la bocca. NON provocare il vomito.
  • P302+P352-IN CASO DI CONTATTO CON LA PELLE: lavare abbondantemente con acqua/.
  • P304+P340-IN CASO DI INALAZIONE: trasportare l'infortunato all'aria aperta e mantenerlo a riposo in posizione che favorisca la respirazione.
  • P312-Contattare un CENTRO ANTIVELENI/un medico/in caso di malessere.
  • P332+P313-In caso di irritazione della pelle: consultare un medico.
  • P337+P313-Se l'irritazione degli occhi persiste, consultare un medico.
 Supplemental information
  • MIXTURE LIST-Contain: DL-Thioctic acid
SDS

RUO – Research Use Only

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