DNA-PK Monoclonal Antibody (3H6), Invitrogen™

Descrizione

MA5-15813 targets PRKDC in indirect ELISA, ICC, IHC, IF and WB applications and shows reactivity with Human samples. The MA5-15813 immunogen is purified recombinant fragment of human PRKDC expressed in E. Coli. MA5-15813 detects PRKDC which has a predicted molecular weight of approximately 46.9kDa.

DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. DNA-PK is an atypical kinase, closely related to the PI3 kinases, and is often potently inhibited by small molecules designed to target PI3 kinases. DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for DNA-PK.