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Docetaxel, 99%

Codice prodotto. 15452989
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Codice prodotto. 15452989 Fornitore Thermo Scientific Alfa Aesar N. del fornitore J60174.03
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Descrizione

Docetaxel, CAS # 114977-28-5, is a cytotoxic, semisynthetic, second-generation taxane derived from the needles of the European yew tree and displays antineoplastic, antibiotic, and antimicrotubule activities. | CAS: 114977-28-5 | C43H53NO14 | 807.89 g/mol

Docetaxel is a second-generation cytotoxic antimicrotubule agent and is mostly used in the pharmaceutical industry.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Docetaxel is an analog of taxol, and is considered to be a cytotoxic, semisynthetic, second-generation taxane that exhibits antineoplastic, antibiotic, and antimicrotubule activities
• Docetaxel is capable of inhibiting cellular mitosis. This compound promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. This stability inhibits the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. This results in the persistence of abnormal microtubule structures leading to cell-cycle arrest and cell death

Application

• Docetaxel can inhibit angiogenesis by acting on vascular endothelial growth factor (VEGF) associated with cancer cells
• This compound has been used to investigate the effect of lysosomal autophagic flux in gastric cancer cells

TRUSTED_SUSTAINABILITY

Identificatori chimici

CAS 114977-28-5
Formula molecolare C43H53NO14
Molecular Weight (g/mol) 807.89
Numero MDL MFCD00800737
InChI Key ZDZOTLJHXYCWBA-VCVYQWHSSA-N
Sinonimo docetaxel, taxotere, docetaxel anhydrous, docetaxol, emdoc, docetaxel, trihydrate, docetaxel inn, taxotere tn, unii-699121phca, txl
PubChem CID 148124
ChEBI CHEBI:4672
SMILES CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O

Specifica

Materiale o nome chimico Docetaxel
Punto di fusione 186°C to 192°C
Colore White
Quantità 1 g
Indice di Merck 14,3397
Informazioni di solubilità Soluble in dimethyl sulfoxide and ethanol; Insoluble in water.
Peso formulazione 807.88
Percent Purity 99%
Forma fisica Powder

RUO – Research Use Only

Titolo del prodotto
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