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Invitrogen™ Doublecortin Polyclonal Antibody

Descrizione
Recommended positive controls: Raji, human DCX-transfected 293T. Predicted reactivity: Mouse (99%), Rat (97%), Chicken (94%), Bovine (96%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.
Specifica
Specifica
| Antigene | Doublecortin |
| Applicazioni | Western Blot, Immunocytochemistry |
| Classificazione | Polyclonal |
| Concentrazione | 0.76 mg/mL |
| Coniugato | Unconjugated |
| Formulazione | 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7 |
| Gene | DCX |
| N. accesso geni | O43602 |
| Alias gene | DBCN; Dbct; DC; Dcn; DCX; doublecortex; doublecortin; doublin; lissencephalin-X; lissencephaly, X-linked (doublecortin); LISX; Lis-X; LIS-XD; Neuronal migration protein doublecortin; OTTHUMP00000023860; OTTHUMP00000216316; SCLH; XLIS |
| Simboli geni | DCX |
| Vedi altri risultati |
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