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Etoposide

Codice prodotto. 15495819
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100 mg
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15495819 25 mg 25mg
15405829 100 mg 100mg
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Codice prodotto. 15495819 Fornitore Thermo Scientific Alfa Aesar N. del fornitore J63651.MB
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Descrizione

Topoisomerase inhibitor and inducer of apoptosis | CAS: 33419-42-0 | C29H32O13 | 588.56 g/mol

Etoposide is used as a inhibits DNA synthesis and is very active against cells in the late S and G2 phases of the cell cycle. Etoposide was reported to be used to serum starve Saos-2 M5(p53-/-) cells which were transfected by electroporation with indicated expression plasmids for flag-E2F1 and myc-EBNA3C for selection of colony forming units, thus studying the blocking effect of EBV Nuclear Antigen 3C on E2F1 Mediated Apoptosis Induced by the DNA Damage Response.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Etoposide is used as a inhibits DNA synthesis and is very active against cells in the late S and G2 phases of the cell cycle. Etoposide was reported to be used to serum starve Saos-2 M5(p53-/-) cells which were transfected by electroporation with indicated expression plasmids for flag-E2F1 and myc-EBNA3C for selection of colony forming units, thus studying the blocking effect of EBV Nuclear Antigen 3C on E2F1 Mediated Apoptosis Induced by the DNA Damage Response.

Solubility
Insoluble in water.

Notes
Store solutions in DMSO at 4°C. For long term storage prepare aliquots and store at -20°C.
TRUSTED_SUSTAINABILITY

Identificatori chimici

CAS 33419-42-0
Formula molecolare C29H32O13
Molecular Weight (g/mol) 588.56
Numero MDL MFCD00869325,MFCD00869325
InChI Key VJJPUSNTGOMMGY-MRVIYFEKSA-N
Sinonimo vjjpusntgommgy-nzlmilqcsa
PubChem CID 50936917
IUPAC Name (10R,11R,15R,16S)-16-{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-10-(4-hydroxy-3,5-dimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0³,⁷.0¹¹,¹⁵]hexadeca-1,3(7),8-trien-12-one
SMILES COC1=CC(=CC(OC)=C1O)[C@H]1[C@@H]2[C@H](COC2=O)[C@H](O[C@@H]2O[C@@H]3CO[C@@H](C)O[C@H]3[C@H](O)[C@H]2O)C2=CC3=C(OCO3)C=C12

Specifica

Materiale o nome chimico Etoposide
Punto di fusione 236°C to 251°C
Colore White
Quantità 25 mg
Indice di Merck 14,3886
Informazioni di solubilità Insoluble in water.
Optical Rotation −107° (c=1 in Methanol/Dichloromethane 1:9)
Peso formulazione 588.56
Forma fisica Powder

RUO – Research Use Only

Titolo del prodotto
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