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FAS/CD95 Mouse anti-Human, Mouse, Clone: 1G7F7, Proteintech
Mouse Monoclonal Antibody
140.00€ - 399.00€
Specifica
Antigene | FAS/CD95 |
---|---|
Clone | 1G7F7 |
Concentrazione | 1.13 mg/mL |
Applicazioni | Flow Cytometry, Western Blot, Immunohistochemistry (Paraffin) |
Classificazione | Monoclonal |
Codice del prodotto | Marca | Quantità | Prezzo | Quantità e disponibilità | |||||
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Codice del prodotto | Marca | Quantità | Prezzo | Quantità e disponibilità | |||||
16807195
|
Proteintech
60196-1-IG-20UL |
20 μL |
140.00€
20µL |
Spedizione stimata: 14-05-2024 Eseguire il login per visualizzare lo stock disponibile |
Effettua il login per acquistare questo articolo Hai bisogno di un conto web ? Registrati oggi stesso! | ||||
16897185
|
Proteintech
60196-1-IG-150UL |
150 μL |
399.00€
150µL |
Spedizione stimata: 14-05-2024 Eseguire il login per visualizzare lo stock disponibile |
Effettua il login per acquistare questo articolo Hai bisogno di un conto web ? Registrati oggi stesso! | ||||
Descrizione
This anti-Fas monoclonal antibody can be used to induce apoptosis in cell cultures through Fas by imitating the Fas-ligand.
FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein that functions as a cell death receptor of the TNFR (tumor necrosis factor receptor) superfamily. FAS also exists in a soluble form that weight approximately 26kDa. Stimulation of FAS results in aggregation of its intracellular FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC) and activation of caspases. The auto-proteolytic processing of the caspases in the complex trigger a downstream cascade that leads to apoptosis. FAS has been shown to activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and is involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full-length isoform. The Fas/Fas ligand system has been shown to play a role in a number of human diseases such as AIDS, hepatitis and cancer. It is also assumed that induction of apoptosis through FAS ligand pathway is predomitly involved in anti-viral immune responses.Specifica
FAS/CD95 | |
1.13 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
ALPS1A, APO 1, Apo 1 antigen, APT1, CD95, FAS, FAS1, FASLG receptor, FASTM, TNFRSF6 | |
FAS | |
IgG1 | |
Protein G | |
Antibody |
1G7F7 | |
Flow Cytometry, Western Blot, Immunohistochemistry (Paraffin) | |
Unconjugated | |
Mouse | |
Human, Mouse | |
P25445, P25446 | |
14102, 355 | |
FAS/CD95 Fusion Protein Ag3718 | |
Primary | |
-20°C | |
FAS |