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Invitrogen™ FLIP Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA519883
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Descrizione
A suggested positive control is Jurkat cell lysate. PA5-19883 can be used with blocking peptide PEP-0014.
FLIP (CFLAR) is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells. It acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
Specifica
| FLIP | |
| Polyclonal | |
| Unconjugated | |
| CFLAR | |
| 2310024N18Rik; A430105C05Rik; Cash; CASP8 and FADD like apoptosis regulator; CASP8 and FADD-like apoptosis regulator; CASP8 and FADD-like apoptosis regulator subunit p12; CASP8 and FADD-like apoptosis regulator subunit p43; CASP8AP1; caspase homolog; Caspase-eight-related protein; caspase-like apoptosis regulatory protein; caspase-related inducer of apoptosis; Casper; Cellular FLICE-like inhibitory protein; Cflar; c-Flip; c-FLIPL; c-FLIPR; c-FLIPS; CLARP; ENSMUSG00000072980; FADD-like antiapoptotic molecule 1; FLAME; FLAME1; FLAME-1; Flip; Gm9845; I-FLICE; Inhibitor of FLICE; MACH-related inducer of toxicity; MRIT; testis secretory sperm-binding protein Li 233m; usurpin; usurpin beta | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 117279, 12633, 8837 | |
| Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C | |
| Liquid |
| Flow Cytometry, Immunohistochemistry, Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| PBS with 0.02% sodium azide | |
| O15519, O35732 | |
| CFLAR | |
| A peptide corresponding to amino acids near the amino terminus of human FLIP. | |
| 100 μg | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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