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Fluconazole, 99%

Codice prodotto. 15474479
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25 g
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Codice prodotto. 15474479 Fornitore Thermo Scientific Alfa Aesar N. del fornitore J62015.14
 Articolo soggetto a restrizioni
Spedizione stimata: 16-11-2026
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Descrizione

Fluconazole, CAS # 86386-73-4, is a synthetic triazole with antifungal activity against some species of Candida. It also shows inhibitory activity against cytochrome P-450 enzymes and it is a demethylase. | CAS: 86386-73-4 | C13H12F2N6O | 306.277 g/mol

Fluconazole is used to treat a variety of fungal infections, especially Candida infections of the vagina (yeast infections), mouth, throat and bloodstream. It is also used by the people having weak immune system such as persons with neutropenia due to cancer chemotherapy, transplanted patients and premature infants.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Fluconazole, 98% is a triazole compound showing antifungal activity mainly against Candida, Coccidioides, and Cryptococcus species
  • It has been shown to inhibit fungal cytochrome P-450 sterol C-14 α-demethylation, resulting in the accumulation of fungal 14 α-methyl sterols, the loss of normal fungal sterols, and associated fungistatic activity
  • It also inhibits cytochrome P450 family 2 subfamily c member 9 (CYP2C9)
  • Mammalian cell demethylation is much less susceptible to fluconazole inhibition

Applications

  • Fluconazole has fungistatic activity against many fungal strains including Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, and Cryptococcus neoformans.
  • Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene
  • In biological experiments, this compound has been used to assess minimum inhibitory concentration in (MIC)-fungal assays
  • It has also been used as a positive control in antifungal assay of plants
TRUSTED_SUSTAINABILITY

Identificatori chimici

CAS 86386-73-4
Formula molecolare C13H12F2N6O
Molecular Weight (g/mol) 306.277
Numero MDL MFCD00274549
InChI Key RFHAOTPXVQNOHP-UHFFFAOYSA-N
Sinonimo fluconazole, diflucan, triflucan, elazor, biozolene, biocanol, fungata, fluconazol, fluconazolum, flucazol
PubChem CID 3365
ChEBI CHEBI:46081
IUPAC Name 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol
SMILES C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O

Specifica

Materiale o nome chimico Fluconazole
Punto di fusione 138°C to 140°C
Colore White
Densità 1.05
Quantità 25 g
Indice di Merck 14,4122
Informazioni di solubilità Soluble indimethylsulfoxide and ethanol.
Peso formulazione 306.27
Percent Purity 99%
Forma fisica Crystalline Powder

RUO – Research Use Only

Titolo del prodotto
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