missing translation for 'onlineSavingsMsg'
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Descrizione
FRS3 (fibroblast growth factor receptor substrate 3), also known as FRS2B (FRS2-beta), is a 492 amino acid lipid-anchor adapter protein that contains one IRS-type PTB domain. Colocalizing to neural tissues with Tuj1, FRS3 functions as a feedback inhibitor of EGFR family members by preventing heterodimer formation between EGFR and ErbB2, thereby acting as a potential tumor suppressor. FRS3 is phosphorylated upon stimulation by FGF-2 or NGF and, acting as an adapter protein, links c-Fgr and NGF receptors to downstream signaling pathways. Interfering with the phosphorylation and nuclear translocation of ERK-2, FRS3 down-regulates ERK-2 expression. FRS3 likely interacts directly with GRB2, SH-PTP2, Flg, and Trk A, and may be involved in MAP kinase activation.
Specifica
Specifica
| Antigene | FRS3 |
| Applicazioni | Immunohistochemistry (Paraffin), Western Blot, Immunofluorescence, Immunocytochemistry |
| Classificazione | Polyclonal |
| Concentrazione | 0.13 mg/mL |
| Coniugato | Unconjugated |
| Formulazione | PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 |
| Gene | FRS3 |
| N. accesso geni | O43559, Q52RG8, Q91WJ0 |
| Alias gene | FGFR signaling adaptor SNT2, FGFR substrate 3, FRS2B, FRS2beta, FRS3, SNT 2, SNT2 |
| Simboli geni | Frs3 |
| Vedi altri risultati |
Titolo del prodotto
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