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  8. Glybenzcyclamide, 99%

Glybenzcyclamide, 99%

Codice prodotto. 11456974
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Quantità:
25 g
Dimensione della confezione:
25g
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Codice prodotto. Quantità unitSize
11456974 25 g 25g
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Codice prodotto. 11456974 Fornitore Thermo Scientific Alfa Aesar N. del fornitore B21459.14
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Descrizione

CAS: 10238-21-8 | C23H28ClN3O5S | 494.003 g/mol

Glyburide (Glibenclamide) is a sulfonylurea compound that modulates insulin production. Sulfonylureas bind to ATP-dependent K+ channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turn stimulates insulin production. Glyburide (Glibenclamide) is an ATP-dependent K+ channel (KIR6, KATP) and CFTR Cl- channel blocker. This compound inhibits recombinant CFTR Cl- channels (IC50 = 20 M).

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Glyburide (Glibenclamide) is a sulfonylurea compound that modulates insulin production. Sulfonylureas bind to ATP-dependent K+ channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turn stimulates insulin production. Glyburide (Glibenclamide) is an ATP-dependent K+ channel (KIR6, KATP) and CFTR Cl- channel blocker. This compound inhibits recombinant CFTR Cl- channels (IC50 = 20 μM).

Solubility
Soluble in ethanol (5 mg/mL), DMSO (25 mg/mL), chloroform (1:36), methanol (1:250), and DMF. Insoluble in water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.
TRUSTED_SUSTAINABILITY

Identificatori chimici

CAS 10238-21-8
Formula molecolare C23H28ClN3O5S
Molecular Weight (g/mol) 494.003
Numero MDL MFCD00056625
InChI Key ZNNLBTZKUZBEKO-UHFFFAOYSA-N
Sinonimo glyburide, glibenclamide, glybenclamide, micronase, diabeta, glynase, daonil, euglucon, maninil, semi-daonil
PubChem CID 3488
ChEBI CHEBI:5441
IUPAC Name 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
SMILES COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3

Specifica

Materiale o nome chimico Glybenzcyclamide
Punto di fusione 171°C to 174°C
Quantità 25 g
Informazioni di solubilità Soluble in ethanol (5mg/mL),DMSO (25mg/mL),chloroform (1:36),methanol (1:250),and DMF. Insoluble in water.
Peso formulazione 494.01
Percent Purity 99%

RUO – Research Use Only

Titolo del prodotto
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