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Thermo Scientific Chemicals Guanidine hydrochloride, Molecular Biology Grade

Product Code. 15440467
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Product Code. 15440467 Supplier Thermo Scientific Chemicals Supplier No. J65661.36
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A protein denaturant | CAS: 50-01-1 | CH6ClN3 | 95.53 g/mol

Guanidine hydrochloride is used for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary. Guanidine hydrochloride is used in RNA isolation to dissociate nucleoproteins and inhibit RNase.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Guanidine hydrochloride is used for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary. Guanidine hydrochloride is used in RNA isolation to dissociate nucleoproteins and inhibit RNase.

Solubility
Freely soluble in water

Notes
Protect from heat. Store away from oxidizing agents.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 50-01-1
Formula molecolare CH6ClN3
Molecular Weight (g/mol) 95.53
Numero MDL MFCD00013026
InChI Key PJJJBBJSCAKJQF-UHFFFAOYSA-N
Sinonimo guanidine hydrochloride, guanidinium chloride, guanidine, monohydrochloride, aminoformamidine hydrochloride, aminomethanamidine hydrochloride, guanidine monohydrochloride, guanidine hcl, guanidine chloride, iminourea hydrochloride, carbamidine hydrochloride
PubChem CID 5742
ChEBI CHEBI:32735
IUPAC Name guanidine;hydrochloride
SMILES C(=N)(N)N.Cl

Specifications

Materiale o nome chimico Guanidine hydrochloride
Punto di fusione 178°C to 185°C
Colore White
Densità 1.34
Quantità 500 g
Beilstein 3591990
Sensibilità Hygroscopic
Indice di Merck 144562
Informazioni di solubilità Freely soluble in water
Peso formulazione 95.53
Grado Biologia molecolare
Forma fisica Crystalline Solid
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Product Identifier
  • Guanidine hydrochloride, Molecular Biology Grade
Signal Word
  • Attenzione
Hazard Category
  • Tossicità acuta Categoria 4
  • Lesione oculare grave/irritazione oculare Categoria 2
  • Corrosione/irritazione della pelle Categoria 2
Hazard Statement
  • H302-Nocivo se ingerito.
  • H315-Provoca irritazione cutanea.
  • H319-Provoca grave irritazione oculare.
  • H332-Nocivo se inalato.
Precautionary Statement
  • P280-Indossare guanti/indumenti protettivi/Proteggere gli occhi/il viso.
  • P301+P330+P331-IN CASO DI INGESTIONE: sciacquare la bocca. NON provocare il vomito.
  • P302+P352-IN CASO DI CONTATTO CON LA PELLE: lavare abbondantemente con acqua/.
  • P304+P340-IN CASO DI INALAZIONE: trasportare l'infortunato all'aria aperta e mantenerlo a riposo in posizione che favorisca la respirazione.
  • P312-Contattare un CENTRO ANTIVELENI/un medico/in caso di malessere.
  • P337+P313-Se l'irritazione degli occhi persiste, consultare un medico.
Supplemental information
  • MIXTURE LIST-Contain: guanidine hydrochloride

RUO – Research Use Only

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