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ACROBiosystems Human KRAS Protein, His Tag
522.57€ - 4062.99€
Specifica
Numero di accesso | NP_004976.2 |
---|---|
Peso molecolare | 21.3 kDa |
Sorgente | Human KRAS, His Tag (KRS-H5547) is expressed from Baculovirus-Insect cells. It contains AA Met 1 - Lys 169 (Accession # P01116-2). |
Immunogeno | Met 1 - Lys 169 |
Requisiti di stoccaggio | -20°C |
Codice del prodotto | Marca | Quantità | Prezzo | Quantità e disponibilità | |||||
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Codice del prodotto | Marca | Quantità | Prezzo | Quantità e disponibilità | |||||
17256290
|
ACROBiosystems
KRS-H5547-100UG |
100 μg |
522.57€
100µg |
Spedizione stimata: 02-05-2024 Eseguire il login per visualizzare lo stock disponibile |
Effettua il login per acquistare questo articolo Hai bisogno di un conto web ? Registrati oggi stesso! | ||||
17266290
|
ACROBiosystems
KRS-H5547-1MG |
1 mg |
4062.99€
1mg |
Spedizione stimata: 02-05-2024 Eseguire il login per visualizzare lo stock disponibile |
Effettua il login per acquistare questo articolo Hai bisogno di un conto web ? Registrati oggi stesso! | ||||
Descrizione
KRAS (Kirsten rat sarcoma 2 viral oncogene homolog) gene is a proto-oncogene that encodes a small GTPase transductor protein called KRAS. KRAS is also known as Ki-Ras, c-K-ras andc-Ki-ras. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation, promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner. RAS is one of the most frequently mutated oncogenes in human cancer but the frequency and distribution of RAS gene mutations are not uniform. In details, mutation of glycine 12 (G12) causes RAS activation by interfering with GAP binding and GAP-stimulated GTP hydrolysis. The reference shows the pathway may as a potential therapy targets.
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 21.3 kDa. The protein migrates as 23-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Specifica
NP_004976.2 | |
Human KRAS, His Tag (KRS-H5547) is expressed from Baculovirus-Insect cells. It contains AA Met 1 - Lys 169 (Accession # P01116-2). | |
-20°C | |
KRAS | |
Human | |
50 mM Tris, 0.5 M NaCl, pH7.5 | |
InsectCells | |
Enzymes |
21.3 kDa | |
Met 1 - Lys 169 | |
GTPase Kras,K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras,KRAS2,RASK2,C-K-RAS,CFC2,K-RAS2A,K-RAS2B,K-RAS4A,K-RAS4B,KI-RAS,KRAS1,KRAS2,NS,NS3,RASK2,KRAS | |
Unconjugated | |
His Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>90% as determined by SDS-PAGE. |