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Hydroxyurea, 98%

Codice prodotto. 10795991 Sfoglia Tutto Thermo Scientific Chemicals Prodotti
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Imballaggio:
Bottiglia in vetro
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Product Code. 10795991 missing translation for 'mfr' Thermo Scientific Acros missing translation for 'supplierNo' 151680050
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Description

Hydroxyurea, 98%, CAS # 127-07-1, is a compound with antineoplastic, immunomodulatory, radical scavenger, and antimitotic activities. It shows inhibitory activity against nucleic acid synthesis. | CAS: 127-07-1 | CH4N2O2 | 76.04 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Hydroxyurea is a member of the class of urea that shows antineoplastic, immunomodulatory, radical scavenger, and antimitotic activities.

• It has inhibitory activity against nucleic acid synthesis.

• It also inhibits ribonucleoside diphosphate reductase, an enzyme necessary to convert ribonucleoside diphosphate into deoxyribonucleoside diphosphate, preventing cells from leaving the G1/S phase of the cell cycle

Applications

• Hydroxyurea has an anti-retroviral activity, inhibiting human immunodeficiency virus type 1 (HIV-1) DNA synthesis in peripheral blood lymphocytes, decreasing the amount of intracellular deoxynucleotides

• This compound also has a radio sensitizing activity, maintaining cells in the radiation-sensitive G1 cell cycle phase and, consequently, interfering with DNA repair

• It has been used for cell cycle synchronization in human breast carcinoma cells

• This compound presents inhibitory activity in cell adhesion and motility assay in ccRCC Caki (HTB-47) and CD9 knockdown cells

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 127-07-1
Formula molecolare CH4N2O2
Molecular Weight (g/mol) 76.04
Numero MDL MFCD00007943
InChI Key VSNHCAURESNICA-UHFFFAOYSA-N
Sinonimo hydroxycarbamide, n-hydroxyurea, hydrea, 1-hydroxyurea, oxyurea, carbamoyl oxime, biosupressin, hydroxycarbamine, onco-carbide, carbamohydroxamic acid
PubChem CID 3657
ChEBI CHEBI:44423
IUPAC Name hydroxyurea
SMILES C(=O)(N)NO

Specifications

Materiale o nome chimico Hydroxyurea
Punto di fusione 142°C to 146°C
Colore White
Perdita all'essiccatura 1% max. (1 g, 60°C) (< 0.7 kPa)
Spettro a infrarossi Authentic
Intervallo percentuale saggio 97.5% min. (on dried substance) (Iodometry)
Imballaggio Bottiglia in vetro
Formula lineare HONHCONH2
Quantità 5 g
Beilstein 03, 95
Indice di Merck 15, 4888
Informazioni di solubilità Solubility in water: freely soluble. Other solubilities: freely soluble in hot alcohol
Peso formulazione 76.04
Percent Purity 98%
Forma fisica Crystalline Powder
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Safety and Handling

compliance-icons
Product Identifier
  • Hydroxyurea
 Signal Word
  • Pericolo
 Hazard Category
  • Mutagenicità di cellule germinali Categoria 1B
  • Tossicità per la riproduzione Categoria 1A
 Hazard Statement
  • H360D-Può nuocere al feto.
  • H340-Può provocare alterazioni genetiche.
 Precautionary Statement
  • P201-Procurarsi istruzioni specifiche prima dell'uso.
  • P308+P313-IN CASO di esposizione o di possibile esposizione, consultare un medico.
SDS

RUO – Research Use Only

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