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Hygromycin B

Codice prodotto. 15403419
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15413419 250 mg 250mg
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Product Code. 15403419 Supplier Thermo Scientific Alfa Aesar Supplier No. J60681.MC
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Description

Hygromycin B, CAS # 31282-04-9, is an aminoglycoside compound showing antibiotic activity that kills bacteria through the inhibition of protein synthesis. It also presents anthelmintic activity. | CAS: 31282-04-9 | C20H37N3O13 | 527.524 g/mol

An aminoglycoside antibiotic that kills bacteria by inhibiting protein synthesisHygromycin B is used for the selection and maintenance of prokaryotic and eukaryotic cells that contains the hygromycin resistance gene. This gene is frequently used as a selectable marker in research on plants. It stabilizes the transfer ribonucleic acid (tRNA)-ribosomal acceptor site, thereby inhibiting translocation. In addition to this, it serves as an aminoglycosidic antibiotic which inhibits protein synthesis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Hygromycin is an aminoglycosidic compound that shows antibiotic activity. It is produced by Streptomyces hygroscopicus
  • Hygromycin acts against both prokaryotic and eukaryotic cells, having the ability to inhibit protein synthesis. It also stabilizes the transfer ribonucleic acid (tRNA)-ribosomal acceptor site, thereby inhibiting translocation. This compound prevents ribosome translocation during translation elongation by binding the 30S rRNA proximal to the ribosomal E, P, and A sites

Application

  • In clinical and plant research, this compound can be used as a marker to select and maintain prokaryotic and eukaryotic cells containing the hygromycin resistance gene
  • Hygromycin also presents an anthelmintic activity against nematode parasites of chickens
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 31282-04-9
Formula molecolare C20H37N3O13
Molecular Weight (g/mol) 527.524
Numero MDL MFCD06795479
InChI Key GRRNUXAQVGOGFE-BBMONYMYSA-N
PubChem CID 134129613
IUPAC Name (3'S,3aS,4S,4'S,5'R,6R,6'R,7R,7aS)-4-[(1R,2S,3R,5S,6S)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy-6'-[(1S)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol
SMILES CNC1CC(C(C(C1O)OC2C3C(C(C(O2)CO)O)OC4(O3)C(C(C(C(O4)C(CO)N)O)O)O)O)N

Specifications

Materiale o nome chimico Hygromycin B
Tipo Hygromycin B
Forma fisica Lyophilized Powder
Colore Brown
Quantità 100 mg
Numero UN UN3462
Indice di Merck 14,4852
Informazioni di solubilità Miscible with water,methanol,buffer solution and ethanol; Immiscible with less polar solvents.
Peso formulazione 527.53

Safety and Handling

compliance-icons compliance-icons compliance-icons
Product Identifier
  • Hygromycin B
 Signal Word
  • Pericolo
 Hazard Category
  • Tossicità acuta Categoria 1
  • Tossicità acuta Categoria 2
  • Lesione oculare grave/irritazione oculare Categoria 1
  • Sensibilizzante delle vie respiratorie Categoria 1
  • Sensibilizzazione della pelle Categoria 1
 Hazard Statement
  • H300-Letale se ingerito.
  • H310-Letale per contatto con la pelle.
  • H317-Può provocare una reazione allergica cutanea.
  • H318-Provoca gravi lesioni oculari.
  • H330-Letale se inalato.
  • H334-Può provocare sintomi allergici o asmatici o difficoltà respiratorie se inalato.
 Precautionary Statement
  • P280-Indossare guanti/indumenti protettivi/Proteggere gli occhi/il viso.
  • P302+P352-IN CASO DI CONTATTO CON LA PELLE: lavare abbondantemente con acqua/.
  • P304+P340-IN CASO DI INALAZIONE: trasportare l'infortunato all'aria aperta e mantenerlo a riposo in posizione che favorisca la respirazione.
  • P305+P351+P338-IN CASO DI CONTATTO CON GLI OCCHI: sciacquare accuratamente per parecchi minuti. Togliere le eventuali lenti a contatto se è agevole farlo. Continuare a sciacquare.
  • P310-Contattare immediatamente un CENTRO ANTIVELENI/un medico .
  • P330-Sciacquare la bocca.
 Supplemental information
  • MIXTURE LIST-Contiene: Hygromycin B
SDS

RUO – Research Use Only

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