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Hygromycin B
Beschreibung
An aminoglycoside antibiotic that kills bacteria by inhibiting protein synthesisHygromycin B is used for the selection and maintenance of prokaryotic and eukaryotic cells that contains the hygromycin resistance gene. This gene is frequently used as a selectable marker in research on plants. It stabilizes the transfer ribonucleic acid (tRNA)-ribosomal acceptor site, thereby inhibiting translocation. In addition to this, it serves as an aminoglycosidic antibiotic which inhibits protein synthesis.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- Hygromycin is an aminoglycosidic compound that shows antibiotic activity. It is produced by Streptomyces hygroscopicus
- Hygromycin acts against both prokaryotic and eukaryotic cells, having the ability to inhibit protein synthesis. It also stabilizes the transfer ribonucleic acid (tRNA)-ribosomal acceptor site, thereby inhibiting translocation. This compound prevents ribosome translocation during translation elongation by binding the 30S rRNA proximal to the ribosomal E, P, and A sites
Application
- In clinical and plant research, this compound can be used as a marker to select and maintain prokaryotic and eukaryotic cells containing the hygromycin resistance gene
- Hygromycin also presents an anthelmintic activity against nematode parasites of chickens
Spezifikation
Spezifikation
| Materiale o nome chimico | Hygromycin B |
| Tipo | Hygromycin B |
| Forma fisica | Lyophilized Powder |
| Colore | Brown |
| Quantità | 1 g |
| Numero UN | UN3462 |
| Indice di Merck | 14,4852 |
| Informazioni di solubilità | Miscible with water,methanol,buffer solution and ethanol; Immiscible with less polar solvents. |
| Peso formulazione | 527.53 |
Sicherheit und Handhabung
- Hygromycin B
- Pericolo
- Tossicità acuta Categoria 1
- Tossicità acuta Categoria 2
- Lesione oculare grave/irritazione oculare Categoria 1
- Sensibilizzante delle vie respiratorie Categoria 1
- Sensibilizzazione della pelle Categoria 1
- H300-Letale se ingerito.
- H310-Letale per contatto con la pelle.
- H317-Può provocare una reazione allergica cutanea.
- H318-Provoca gravi lesioni oculari.
- H330-Letale se inalato.
- H334-Può provocare sintomi allergici o asmatici o difficoltà respiratorie se inalato.
- P280-Indossare guanti/indumenti protettivi/Proteggere gli occhi/il viso.
- P302+P352-IN CASO DI CONTATTO CON LA PELLE: lavare abbondantemente con acqua/.
- P304+P340-IN CASO DI INALAZIONE: trasportare l'infortunato all'aria aperta e mantenerlo a riposo in posizione che favorisca la respirazione.
- P305+P351+P338-IN CASO DI CONTATTO CON GLI OCCHI: sciacquare accuratamente per parecchi minuti. Togliere le eventuali lenti a contatto se è agevole farlo. Continuare a sciacquare.
- P310-Contattare immediatamente un CENTRO ANTIVELENI/un medico .
- P330-Sciacquare la bocca.
- MIXTURE LIST-Contain: Hygromycin B
RUO – Research Use Only
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