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DiscoverX InCELL Hunter™ A549 BTK Kinase Binding Cell Line

Codice prodotto. 17344809
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Quantità:
2 Vials
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Codice prodotto. Quantità
17344809 2 Vials
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Codice prodotto. 17344809 Fornitore DiscoverX N. del fornitore 960056C15

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Les retours ne sont pas autorisés pour ce produit. Consulta la politica di reso

Descrizione

The InCELL Hunter™ A549 BTK Kinase Binding Cell Line measures target engagement via compound-induced stabilization of BTK target protein. This cell line ships as two vials of cryopreserved cells.

The InCELL Hunter™ A549 BTK Kinase Binding Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with kinases. This cell line enables assessment of compound-engagement-based stabilization of BTK via detection of BTK levels. This product uses EFC technology. The cell line included overexpresses BTK target protein fused to PL. In the absence of compound that binds and stabilizes the target, this protein is denatured by the heat treatment and no EFC signal is produced. When compound engages and heat-stabilizes the target, EA contained in the detection reagent produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifica

Assay Entry Target Engagement
Linea cellulare A549
Da utilizzare con (applicazione) Cell Lines
Quantità 2 Vials
Target Entry BTK
Titolo del prodotto
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