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DiscoverX InCELL Hunter™ HEK 293 CLK1 Kinase Binding Cell Line

Codice prodotto. 17314819
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Quantità:
2 Vials
Dimensione della confezione:
2 fiale
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Codice prodotto. Quantità unitSize
17314819 2 Vials 2 fiale
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Codice prodotto. 17314819 Fornitore DiscoverX N. del fornitore 960059C1

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Les retours ne sont pas autorisés pour ce produit. Consulta la politica di reso

Descrizione

The InCELL Hunter™ HEK 293 CLK1 Kinase Binding Cell Line measures target engagement via compound-induced stabilization of CLK1 target protein. This cell line ships as two vials of cryopreserved cells.

The InCELL Hunter™ HEK 293 CLK1 Kinase Binding Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with kinases. This cell line enables assessment of compound-engagement-based stabilization of CLK1 via detection of CLK1 levels. This product uses EFC technology. The cell line included overexpresses CLK1 target protein fused to PL. In the absence of compound that binds and stabilizes the target, this protein is denatured by the heat treatment and no EFC signal is produced. When compound engages and heat-stabilizes the target, EA contained in the detection reagent produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifica

Assay Entry Target Engagement
Linea cellulare 293H
Da utilizzare con (applicazione) Cell Lines
Quantità 2 Vials
Target Entry CLK1
Titolo del prodotto
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