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Thermo Scientific Chemicals Indomethacin

Codice prodotto. 15462202 Sfoglia Tutto Thermo Scientific Chemicals Prodotti
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Codice prodotto. 15462202 Fornitore Thermo Scientific Chemicals N. del fornitore 458030050
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Description

Indomethacin, CAS # 53-86-1, is an indole-based nonsteroidal anti-inflammatory (NSAID). | CAS: 53-86-1 | C19H16ClNO4 | 357.79 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Indomethacin is a synthetic NSAID of the indole family that inhibits cyclooxygenase and reduces prostaglandin and pyrogen release

• Indomethacin may suppress the multi-drug resistant transporter and thereby increase the efficacy of antineoplastics

• Indomethacin activates phosphatases that inhibit signaling pathways associated with cancer cell migration and proliferation

Applications

• Indomethacin may be used for the laboratory study of cancer cell proliferation, tumorigenesis and drug interactions

• Indomethacin may be used for laboratory study of the effect of inhibiting the multi-drug resistance transporter, or for downregulation of survival signaling in cells via survivin

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 53-86-1
Formula molecolare C19H16ClNO4
Molecular Weight (g/mol) 357.79
InChI Key CGIGDMFJXJATDK-UHFFFAOYSA-N
Sinonimo indomethacin, indometacin, indocin, indometacine, indomethacine, indocid, metindol, amuno, indomethazine, imbrilon
PubChem CID 3715
ChEBI CHEBI:49662
IUPAC Name 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
SMILES CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O

Specifications

Materiale o nome chimico Indomethacin
Punto di fusione 155.0°C
Perdita all'essiccatura 0.5% max. (100°C, 2 h, 5 mm Hg)
Spettro a infrarossi Authentic
Quantità 5 g
Peso formulazione 357.79
Percent Purity ≥97.5% (HPLC)

Safety and Handling

compliance-icons compliance-icons
Product Identifier
  • Indomethacin
 Signal Word
  • Pericolo
 Hazard Category
  • Tossicità acuta Categoria 1
  • Sensibilizzazione della pelle Categoria 1
  • Tossicità per la riproduzione Categoria 1B
 Hazard Statement
  • H300-Letale se ingerito.
  • H317-Può provocare una reazione allergica cutanea.
  • H360FD-Può nuocere alla fertilità. Può nuocere al feto.
 Precautionary Statement
  • P301+P310-IN CASO DI INGESTIONE: contattare immediatamente un CENTRO ANTIVELENI/un medico/
  • P330-Sciacquare la bocca.
  • P302+P352-IN CASO DI CONTATTO CON LA PELLE: lavare abbondantemente con acqua/sapone.
  • P201-Procurarsi istruzioni specifiche prima dell'uso.
  • P280-Indossare guanti/indumenti protettivi/Proteggere gli occhi/il viso.
  • P308+P313-IN CASO di esposizione o di possibile esposizione, consultare un medico.

RUO – Research Use Only

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