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Indomethacin, 99+%

Codice prodotto. 15425529
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Codice prodotto. 15425529 Fornitore Thermo Scientific Alfa Aesar N. del fornitore J63255.03
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Descrizione

Indomethacin, CAS # 53-86-1, is an indole-based nonsteroidal anti-inflammatory (NSAID). | CAS: 53-86-1 | C19H16ClNO4 | 357.79 g/mol

Non-selective cyclooxygenase inhibitorIndomethacin acts as an antiinflammatory, antipyretic and analgesic. It serves as an inhibitor cyclooxygenase such as Cox-1 and Cox-2. In addition to this, it is used as a prescription medication in order to reduce fever, stiffness, swelling and pain.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Indomethacin is a synthetic NSAID of the indole family that inhibits cyclooxygenase and reduces prostaglandin and pyrogen release
  • Indomethacin may suppress the multi-drug resistant transporter and thereby increase the efficacy of antineoplastics
  • Indomethacin activates phosphatases that inhibit signaling pathways associated with cancer cell migration and proliferation

Applications

  • Indomethacin may be used for the laboratory study of cancer cell proliferation, tumorigenesis and drug interactions
  • Indomethacin may be used for laboratory study of the effect of inhibiting the multi-drug resistance transporter, or for downregulation of survival signaling in cells via survivin
TRUSTED_SUSTAINABILITY

Identificatori chimici

CAS 53-86-1
Formula molecolare C19H16ClNO4
Molecular Weight (g/mol) 357.79
Numero MDL MFCD00057095
InChI Key CGIGDMFJXJATDK-UHFFFAOYSA-N
Sinonimo indomethacin, indometacin, indocin, indometacine, indomethacine, indocid, metindol, amuno, indomethazine, imbrilon
PubChem CID 3715
ChEBI CHEBI:49662
IUPAC Name 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
SMILES CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O

Specifica

Materiale o nome chimico Indomethacin
Punto di fusione 158°C to 161°C
Colore White
Quantità 1 g
Numero UN UN2811
Beilstein 497341
Sensibilità Light sensitive
Indice di Merck 14,4968
Informazioni di solubilità Soluble in ethanol and dimethyl sulfoxide.
Peso formulazione 357.8
Percent Purity ≥99%
Forma fisica Powder
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RUO – Research Use Only

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