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Invitrogen™ Integrin beta 7 Monoclonal Antibody (473207)
Mouse Monoclonal Antibody
Marca: Invitrogen™ MA524192
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Descrizione
In Western blots, no cross-reactivity with recombinant human Integrin beta 1, beta 2, beta 3, beta 4, beta 5, beta 6, beta 8, recombinant mouse Integrin beta 4, or beta 7 is observed. Reconstitute at 0.5 mg/mL in sterile PBS.
Integrin beta 7 associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin HML-1, expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Ligands for LPAM-1 include VCAM-1 (CD106), MAdCAM-1 and fibronectin, while the ligand of HML-1 is E-cadherin (CD324). Integrin beta 7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response.
Specifica
| Integrin beta 7 | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with 5% trehalose and No Preservative | |
| P26010 | |
| ITGB7 | |
| CHO-derived recombinant human Integrin beta 7 long isoform Glu20-His723. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Flow Cytometry, Immunocytochemistry | |
| 473207 | |
| Unconjugated | |
| ITGB7 | |
| Gut homing receptor beta subunit; integrin beta 7; integrin beta 7 subunit; integrin beta-7; Integrin beta-P; integrin subunit beta 7; integrin, beta 7; ITGB7; Ly69; M290 IEL antigen | |
| Mouse | |
| Protein A/G | |
| RUO | |
| 3695 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Lyophilized |
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