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  8. L(+)-Amethopterin hydrate, 99%

L(+)-Amethopterin hydrate, 99%

Codice prodotto. 10491631 Sfoglia Tutto Thermo Scientific Chemicals Prodotti
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Codice prodotto. 10491631 Fornitore Thermo Scientific Acros N. del fornitore 208101000
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Descrizione

L(+)-Amethopterin hydrate, CAS # 133073-73-1, is an effective inhibitor of dihydrofolate reductase, which may have anti-tumor activity. | CAS: 133073-73-1 | C20H22N8O5 | 454.45 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • L(+)-Amethopterin hydrate, is a potent inhibitor of dihydrofolate reductase
  • It has tumoricidal activity

Applications

  • L(+)-Amethopterin hydrate is an inhibitor of dihydrofolate reductase
  • It can be used in anti-tumor studies
  • It is a cell cycle arrest agent, which can inhibit synthesis of DNA, RNA, and proteins
  • It can also inhibit production of pro-inflammatory cytokines
TRUSTED_SUSTAINABILITY

Identificatori chimici

CAS 133073-73-1
Formula molecolare C20H22N8O5
Molecular Weight (g/mol) 454.45
Numero MDL MFCD00150847
InChI Key FBOZXECLQNJBKD-UGPWUYPHNA-N
Sinonimo l +-amethopterin dihydrate, methotrexate dihydrate, dihydrate methotrexate, 2s-2-4-2,4-diaminopteridin-6-yl methyl methylamino phenyl carbonylamino pentanedioic acid, hydrate, hydrate
PubChem CID 45157423
IUPAC Name (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;dihydrate
SMILES CN(CC1=CN=C2N=C(N)N=C(N)C2=N1)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O

Specifications

Materiale o nome chimico L(+)-Amethopterin hydrate
Punto di fusione 195°C
Colore Yellow to Orange
Spettro a infrarossi Authentic
Intervallo percentuale saggio 98.5% min. (HPLC)
Imballaggio Glass Bottle
Quantità 100 mg
Indice di Merck 14, 5985
Rotazione specifica + 21.5
Informazioni di solubilità Solubility in water: insoluble in water. Other solubilities: insoluble in alcohol,chloroform,ether,slightly soluble in dilute hydrochloric acid,soluble in dilute solutions of alkali hydroxides a
Peso formulazione 454.44
Percent Purity 99%
Forma fisica Crystalline Powder
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Safety and Handling

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Product Identifier
  • L(+)-Amethopterin hydrate
 Signal Word
  • Pericolo
 Hazard Category
  • Tossicità acuta Categoria 3
  • Mutagenicità di cellule germinali Categoria 1B
  • Tossicità per la riproduzione Categoria 1A
 Hazard Statement
  • H360D-Può nuocere al feto.
  • H340-Può provocare alterazioni genetiche.
  • H301-Tossico se ingerito.
 Precautionary Statement
  • P201-Procurarsi istruzioni specifiche prima dell'uso.
  • P301+P310-IN CASO DI INGESTIONE: contattare immediatamente un CENTRO ANTIVELENI/un medico/
  • P308+P313-IN CASO di esposizione o di possibile esposizione, consultare un medico.
SDS

RUO – Research Use Only

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