Thermo Scientific Chemicals LB Broth (Miller's modification)

General Description

• (+)-Dehydroisoandrosterone is an endogenous steroid hormone precursor that acts as an intermediate in the conversion of cholesterol to androgens and estrogens

Applications

• It is an endogenous and naturally occurring steroid hormone produced largely by the adrenal glands, but also by the testes and ovaries
• It has been described that (+)-Dehydroisoandrosterone could have a role in the immune and stress response
• (+)-Dehydroisoandrosterone can be converted to testosterone, androstenedione, estradiol, and estrone
• (+)-Dehydroisoandrosterone is derived from cholesterol through the action of two cytochrome P450 enzymes
• It can induce both direct and indirect in vivo biological effects, by modulating GABA- α receptor and N-Methyl-D-aspartic acid (NMDA) receptor complexes.
• It can also increase pancreatic β cell insulin secretion and anti-glucocorticoid activity
• It is useful to detect excess adrenal activity since it is produced nearly exclusively by the adrenal glands