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Lovastatin, 97%

Codice prodotto. 15499537
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Quantità:
5 g
25 g
Dimensione della confezione:
25g
5g
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Codice prodotto. Quantità Dimensione della confezione
15499537 25 g 25g
15489537 5 g 5g
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Codice prodotto. 15499537 Fornitore Thermo Scientific Alfa Aesar N. del fornitore H52792.14
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Spedizione stimata: 23-10-2026
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Descrizione

CAS: 75330-75-5 | C24H36O5 | 404.55 g/mol

Lovastatin is a cholesterol lowering drug and competitive inhibitor of HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. It increases cellular resistance to anticancer agents such as doxorubicin and induces apoptosis in myeloma cells. It causes cell cycle arrest in G1 and G2/M phases.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Lovastatin is a cholesterol lowering drug and competitive inhibitor of HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. It increases cellular resistance to anticancer agents such as doxorubicin and induces apoptosis in myeloma cells. It causes cell cycle arrest in G1 and G2/M phases.

Solubility
Soluble in DMSO (10 mg/ml), ethanol (10 mg/ml), methanol, chloroform, acetone, acetonitrile, DMF, and water (0.4 µg/ml).

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents and heat.
TRUSTED_SUSTAINABILITY

Identificatori chimici

CAS 75330-75-5
Formula molecolare C24H36O5
Molecular Weight (g/mol) 404.55
Numero MDL MFCD00072164
InChI Key PCZOHLXUXFIOCF-BXMDZJJMSA-N
Sinonimo lovastatin, mevinolin, mevacor, monacolin k, lovalip, altoprev, lovalord, mevinacor, nergadan, 6alpha-methylcompactin
PubChem CID 53232
ChEBI CHEBI:40303
IUPAC Name (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
SMILES CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12

Specifica

Materiale o nome chimico Lovastatin
Punto di fusione 175°C
Quantità 25 g
Informazioni di solubilità Soluble in DMSO (10mg/ml),ethanol (10mg/ml),methanol,chloroform,acetone,acetonitrile,DMF,and water (0.4 μg/ml).
Peso formulazione 404.56
Percent Purity 97%

RUO – Research Use Only

Titolo del prodotto
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