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Tocris Bioscience™ NAMPT PROTAC™ A7
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Codice prodotto. 30000028
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Quantità:
5 mg
Dimensione della confezione:
5mg
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Codice prodotto. Quantità unitSize
30000028 5 mg 5mg
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Codice prodotto. 30000028 Fornitore Tocris Bioscience™ N. del fornitore 7842/5
  • ONLINE EXCLUSIVE PRICE
    516.00€
    487.20€ / 5mg
    Risparmia 28.80€
    5% Sconto
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Spedizione stimata: 03-08-2026
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Descrizione

Potent and selective nicotinamide phosphoribosyl transferase (NAMPT) Degrader (PROTAC™;)

NAMPT PROTAC A7 is a potent and selective intracellular nicotinamide phosphoribosyl transferase (iNAMPT) Degrader (PROTAC™;) (IC50 of 9.5 nM against the enzymatic activity of NAMPT). Comprises a potent NAMPT inhibitor joined by a linker to a ligand for Von Hippel-Lindau (VHL) protein. Proteomic analysis of global protein level changes confirms selectivity. NAMPT PROTAC A7 decreases iNAMPT level and the secretion of extracellular NAMPT (eNAMPT) in CT26 or MC38 cells. In CT26 tumor bearing BALB/c mice, the compound degrades tumoral NAMPT, and boosts antitumor immunity by inhibiting tumor infiltrating myeloid-derived suppressive cells.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

TRUSTED_SUSTAINABILITY

Specifica

Materiale o nome chimico (2S,4R)-1-((S)-18-(tert-Butyl)-1,16-dioxo-1-(4-((4-((4-(3-(pyridin-3-ylmethyl)thioureido)phenyl)sulfonyl)piperazin-1-yl)methyl)phenyl)-5,8,11,14-tetraoxa-2,17-diazanonadecan-19-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-ca
CAS 2484876-94-8
Quantità 5 mg
Bersaglio Active Degraders
Formula molecolare C58H76N10O11S3
Purezza 0.98
Titolo del prodotto
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