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Oligomycin

Codice prodotto. 15414389
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Quantità:
10 mg
Dimensione della confezione:
10mg
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Codice prodotto. Quantità Dimensione della confezione
15414389 10 mg 10mg
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Codice prodotto. 15414389 Fornitore Thermo Scientific Alfa Aesar N. del fornitore J61898.MA
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Descrizione

Oligomycin, CAS # 1404-19-9, is a macrolide antibiotic that inhibits oxidative phosphorylation through blocking mitochondrial ATP synthase. | CAS: 1404-19-9 | C45H74O11 | 791.08 g/mol

Inhibits respiration in mitochondria. Also inhibits ATP synthase

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Oligomycin is a macrolide produced by Streptomyces diastatochromogenes that is toxic to other organisms
  • Oligomycin blocks oxidative phosphorylation through inhibition of ATP synthase. The compound binds to the proton channel of ATP synthase and blocks mitochondrial proton import, resulting in accumulation of cytoplasmic protons
  • Oligomycin also inhibits Na+/K+ exchange through Na+ occlusion within the Na/K-ATPase
  • Oligomycin is provided as a mixture of A, B, and C isomers

Application

  • Oligomycin inhibits respiration in mitochondria. It also inhibits ATP synthase
  • Oligomycin can induce apoptosis in cultured human hepatocarcinoma and other mammalian cells in laboratory settings
TRUSTED_SUSTAINABILITY

Specifica

Materiale o nome chimico Oligomycin
Tipo Oligomycin
Forma fisica Powder
CAS 1404-19-9
Colore White
Quantità 10 mg
Formula molecolare C45H74O11
Numero MDL MFCD00065705,MFCD01779388
Beilstein 7615308
Indice di Merck 14,6833
Informazioni di solubilità Sparingly soluble in water; Soluble in DMSO (20mg/ml) and ethanol (30mg/ml) /n
InChI Key MNULEGDCPYONBU-ZUSSGZTJNA-N
SMILES CCC1CCC2OC3(CCC(C)C(CC(C)O)O3)C(C)C(OC(=O)\C=C\C(C)C(O)C(C)C(=O)C(C)C(O)C(C)C(=O)C(C)(O)C(O)C(C)C\C=C\C=C/1)C2C
IUPAC Name (4E,18E,20Z)-22-ethyl-7,11,14,15-tetrahydroxy-6'-(2-hydroxypropyl)-5',6,8,10,12,14,16,28,29-nonamethyl-2,26-dioxaspiro[bicyclo[23.3.1]nonacosane-27,2'-oxane]-4,18,20-triene-3,9,13-trione
Molecular Weight (g/mol) 791.08
PubChem CID 78358496
Peso formulazione 791.07
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