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ONX-0914, MedChemExpress

Codice prodotto. 16491717
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Codice prodotto. 16491717 Fornitore Medchem Express N. del fornitore HY13207

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Descrizione

MedChemExpress ONX-0914 (PR-957) is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (Ki=5.2 μM). ONX-0914 reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1.

ONX-0914 (PR-957) is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (Ki=5.2 μM). ONX-0914 reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1.

Specifica

Materiale o nome chimico ONX-0914
CAS 960374-59-8
Colore White
Note sul grado di purezza Research
Formula molecolare C31H40N4O7
Quantità 50 mg
Sinonimo PR-957
Informazioni di solubilità DMSO : ≥ 35 mg/mL (60.28 mM)
SMILES O=C(N[C@@H](C)C(N[C@@H](CC1=CC=C(OC)C=C1)C(N[C@@H](CC2=CC=CC=C2)C([C@]3(C)OC3)=O)=O)=O)CN4CCOCC4
Molecular Weight (g/mol) 580.67
Peso formulazione 580.67
Percent Purity 95.03%
Grado Research
Forma fisica Solid
Da utilizzare con (applicazione) COVID-19-immunoregulation
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Research purposes only

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