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p53 Antibody (TRP/816), Alexa Fluor™ 405, Novus Biologicals™

Codice prodotto. 18266941 Sfoglia Tutto Bio Techne Prodotti
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Quantità:
100 μL
Dimensione della confezione:
100µL
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Codice prodotto. Quantità unitSize
18266941 100 μL 100µL
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Codice prodotto. 18266941 Fornitore Novus Biologicals N. del fornitore NBP259628AF405

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Description

Mouse Monoclonal Antibody

p53 Monoclonal specifically detects p53 in Human samples. It is validated for Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin, Knockout Validated.
TRUSTED_SUSTAINABILITY

Specifications

Antigene p53
Applicazioni Western Blot, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunoassay, Immunofluorescence
Classificazione Monoclonal
Clone TRP/816
Coniugato Alexa Fluor 405
Diluizione Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin, Knockout Validated
Formulazione 50mM Sodium Borate with 0.05% Sodium Azide
Alias gene Antigen NY-CO-13, FLJ92943, LFS1TRP53, p53, p53 tumor suppressor, P53cellular tumor antigen p53, Phosphoprotein p53, transformation-related protein 53, tumor protein p53, Tumor suppressor p53
Simboli geni TP53
Specie ospite Mouse
Immunogeno Recombinant human full-length p53 protein (Uniprot: P04637)
Metodo di purificazione Protein A or G purified
Quantità 100 μL
Status giuridico RUO
Disciplina di ricerca Apoptosis, Cancer, Cell Cycle and Replication, Cellular Markers, Checkpoint signaling, Core ESC Like Genes, DNA Double Strand Break Repair, DNA Repair, HIF Target Genes, Hypoxia, Neuroscience, Neurotransmission, p53 Pathway, Phospho Specific, Stem Cell Markers, Transcription Factors and Regulators, Tumor Suppressors
Primario o secondario Primary
ID gene (immissione) 7157
Test di specificità The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a 53kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Target Species Human
Content And Storage Store at 4C in the dark.
Forma Purified
Isotype IgG2a κ
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For Research Use Only (RUO)

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