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DiscoverX PathHunter™ CCR6 Activated GPCR Internalization U2OS Cell Line

Codice prodotto. 17324119
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Quantità:
2 Vials
Dimensione della confezione:
2 fiale
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Codice prodotto. Quantità unitSize
17324119 2 Vials 2 fiale
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Codice prodotto. 17324119 Fornitore DiscoverX N. del fornitore 930966C3

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Descrizione

The PathHunter™ CCR6 Activated GPCR Internalization U2OS Cell Line measures CCR6 (GPCR) internalization via early-endosome localization. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ CCR6 Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line enables assessment of ligand (e.g. CCL20) based internalization of CCR6 via detection of localization to the early endosome. This product uses EFC technology. The included cell line overexpresses EA-tagged β-arrestin 2 as well as a PK-tagged early endosome protein and untagged CCR6. Upon ligand-induced receptor activation, β-arrestin 2 is recruited to the activated GPCR and the resulting CCR6-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifica

Assay Entry Receptor Internalization
Linea cellulare U2OS
Da utilizzare con (applicazione) Cell Lines
Primary Agonist Recombinant Human MIP-3α (CCL20)
Quantità 2 Vials
Target Entry CCR6
Numero di accesso AY242126
Titolo del prodotto
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